Effects of environmental toxicants on development of a teleost embryo
Embryos of the teleost Fundulus heteroclitus are shown to be useful model systems for monitoring the effects of xenobiotic compounds on development. Fourteen different substances were tested: malathion, aroclor, aldrin, diquat, parathion, pentachlorophenol, sevin, toxaphene, lindane, 2,4-D, DDT, paraquat, 2,4,5-T, and aminotriazole. Concentrations used for each of these was from 0.01 to 10.0 ppm in the incubation dishes. The variety of effects on development observed depended on the compound and its concentration. These effects included inhibition of gastrulation, abnormal axis formation, diminished pigmentation, slowed rate of development, reduced frequency of hatching, loss of neuromuscular control, and reduction or inhibition of heart beat. Possible modes of action of some of these compounds are discussed. It is also shown that embryogenesis is not always the most susceptible part of the organism's life cycle.
- Research Organization:
- Trinity College, Hartford, CT
- OSTI ID:
- 5682992
- Journal Information:
- J. Environ. Pathol., Toxicol. Oncol.; (United States), Vol. 2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CHLORINATED AROMATIC HYDROCARBONS
BIOLOGICAL EFFECTS
FISHES
ONTOGENESIS
PESTICIDES
PHENOLS
ALDRIN
BIOLOGICAL MODELS
DDT
MALATHION
PARATHION
POLLUTANTS
WATER POLLUTION
ANIMALS
AQUATIC ORGANISMS
AROMATICS
CARBOXYLIC ACID ESTERS
ESTERS
HALOGENATED AROMATIC HYDROCARBONS
HYDROXY COMPOUNDS
INSECTICIDES
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANIC SULFUR COMPOUNDS
POLLUTION
THIOLS
THIOPHOSPHORIC ACID ESTERS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)