Trace elements determinations in cancerous and non-cancerous human tissues using instrumental neutron activation analysis
Recent improvements in analyzing techniques when coupled to the growing knowledge of trace element biochemistry provide a powerful tool to investigate the relationship between trace elements and cancer. It is hoped that selective delivery or restriction of specific minerals may aid in cancer prevention or treatment. Tissues were collected at the time of surgery of various cancer patients including colon cancer and breast cancer. Three kinds of tissues were taken from a patient; cancerous, noncancerous, and transitional tissue obtained from a region located between the cancer and healthy tissues. A total of 57 tissues were obtained from 19 cancer patients. Seven of them were colon cancer patients, and 5 of them were breast cancer patients. Nine elements were determined using instrumental activation analysis. Cancerous colon tissue had significantly higher concentrations of selenium and iron than healthy tissues. Cancerous breast tissue had significantly higher concentrations of selenium, iron, manganese, and rubidium than healthy tissues. Iron can be enriched in cancer tissue because cancer tissue retains more blood vessels. Selenium is enriched in cancer tissue, possibly in an effort of the body to inhibit the growth of tumors. The manganese enrichment can be explained in the same manner as selenium considering its suspected anticarcinogenicity. It is not certain why rubidium was enriched in cancer tissue. It could be that this is the result of alteration of cell membrane permeability, change in extracellular matrix, or increased metabolism in cancer tissue.
- Research Organization:
- Georgia Inst. of Tech., Atlanta, GA (United States)
- OSTI ID:
- 5669969
- Resource Relation:
- Other Information: Thesis (Ph. D.)
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ANIMAL TISSUES
NEUTRON ACTIVATION ANALYSIS
LARGE INTESTINE
NEOPLASMS
MAMMARY GLANDS
CELL MEMBRANES
CHEMICAL COMPOSITION
IRON
MAN
MANGANESE
PERMEABILITY
SELENIUM
TRACE AMOUNTS
ACTIVATION ANALYSIS
ANIMALS
BODY
CELL CONSTITUENTS
CHEMICAL ANALYSIS
DIGESTIVE SYSTEM
DISEASES
ELEMENTS
GASTROINTESTINAL TRACT
GLANDS
INTESTINES
MAMMALS
MEMBRANES
METALS
ORGANS
PRIMATES
SEMIMETALS
TISSUES
TRANSITION ELEMENTS
VERTEBRATES
550901* - Pathology- Tracer Techniques