Toxic Hazards Research Unit, 1989. Annual report, 1 Oct 88-30 Sep 89

Technical Report · Mon Oct 01 00:00:00 EDT 1990

OSTI ID:5668859

Kutzman, R S; Wall, H G; Vinegar, A

This report has been prepared as a review of the October 1988 through September 1989 activities of the Toxic Hazards Research Unit. Research activities largely focused on the toxicity of chlorotrifluoroethylene oligomers and the acid metabolic products of this material. Initial acute studies also were conducted on a silahydrocarbon hydraulic fluid. Physiologically based pharmacokinetic models were developed, refined or more substantially validated for several chemicals of Air Force and Navy interest. These included hydraulic fluids, organophosphates, and combustion products. Both in vivo and in vitro studies on chloropentafluorobenzene, a chemical defense training material, were conducted or subcontracted, and efforts were begun to develop the equipment needed for additional studies using primates. Neurotoxicity assessments were conducted for jet engine oils and a model was developed to assess the dermal penetration of a neurotoxic compound found in the combustion products of another lubricating oil.

• Research Organization: NSI Technology Services Corp., Dayton, OH (United States)
• OSTI ID: 5668859
• Report Number(s): AD-A-231922/6/XAB
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
COMBUSTION PRODUCTS
TOXICITY
HYDRAULIC FLUIDS
LUBRICATING OILS
IN VITRO
IN VIVO
METABOLISM
NERVOUS SYSTEM
PRIMATES
ANIMALS
FLUIDS
LUBRICANTS
MAMMALS
OILS
ORGANIC COMPOUNDS
OTHER ORGANIC COMPOUNDS
PETROLEUM PRODUCTS
VERTEBRATES
WORKING FLUIDS
560300* - Chemicals Metabolism & Toxicology