Metabolism and disposition of the flame retardant plasticizer, tri-p-cresyl phosphate, in the rat
The metabolism and disposition of tri-p-cresyl phosphate (TPCP) were studied in the rat after a single oral administration of (methyl-/sup 14/C) TPCP. At a dosage of 7.8 mg/kg, most of the administered radioactivity was excreted in the urine (41%) and feces (44%) in 7 days. For 3 days, the expiratory excretion as /sup 14/CO/sub 2/ amounted to 18% of the radioactivity, but was reduced to 3% by treatment of the animal with neomycin. In separate rats, the biliary excretion amounted to 28% of the dose in 24 hr. At a dose of 89.6 mg/kg, the radioactivity was excreted in urine (12%) and feces (77%) in 7 days, and the expired air (6%) in 3 days. At 24, 72, and 168 hr after oral administration, the concentration of radioactivity was relatively high in adipose tissue, liver, and kidney. The major urinary metabolites were p-hydroxybenzoic acid, di-p-cresyl phosphate (DCP), and p-cresyl p-carboxyphenyl phosphate (1coDCP). The biliary metabolites were DCP, 1coDCP, and the oxidized triesters, di-p-cresyl p-carboxyphenyl phosphate (1coTPCP), and p-cresyl di-p-carboxyphenyl phosphate (2coTPCP). The main fecal metabolite was TPCP, and the others were similar to those of bile. Following oral administration, TPCP was absorbed from the intestine, distributed to the fatty tissues, and moderately metabolized to a variety of products of oxidation and dearylation of TPCP, which were then excreted in the urine, feces, bile, and expired air. The intestinal microflora appeared to play an important role in degrading biliary metabolites to /sup 14/CO/sub 2/ through the enterohepatic circulation in rats.
- Research Organization:
- National Institute of Hygienic Sciences, Tokyo, Japan
- OSTI ID:
- 5665945
- Journal Information:
- Toxicol. Appl. Pharmacol.; (United States), Vol. 77:3
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
PHOSPHATES
INTESTINAL ABSORPTION
METABOLISM
ADIPOSE TISSUE
CARBON 14 COMPOUNDS
CARBON DIOXIDE
EXCRETION
FECES
KIDNEYS
LIVER
METABOLITES
NEOMYCIN
ORAL ADMINISTRATION
PLASTICIZERS
RATS
RETENTION
TRACER TECHNIQUES
URINE
ABSORPTION
ANIMAL TISSUES
ANIMALS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
BODY FLUIDS
CARBON COMPOUNDS
CARBON OXIDES
CHALCOGENIDES
CLEARANCE
CONNECTIVE TISSUE
DIGESTIVE SYSTEM
DRUGS
GLANDS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MATERIALS
ORGANS
OXIDES
OXYGEN COMPOUNDS
PHOSPHORUS COMPOUNDS
RODENTS
TISSUES
UPTAKE
VERTEBRATES
WASTES
550501* - Metabolism- Tracer Techniques
560305 - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)