Microwave-induced local hyperthermia in combination with radiotherapy of human malignant tumors
Since 1976, two groups of patients have been treated with local microwave hyperthermia immediately following ionizing radiation. Group A patients had measurable multiple lesions assigned radiotherapy only, microwave hyperthermia only, or combined treatment. Ionizing radiation in 200 to 600 rad fractions was used 2 to 5 times per week to a total of 1800 to 4200 rad in 5 to 14 fractions. Group B patients had combination treatment only, with radiation fractions of 200 to 600 rad 2 to 5 times per week to a total of 200 to 4800 rad total in 6 to 20 fractions. Both groups received hyperthermia (42 to 44 C) 2 to 3 times per week, maximum ten sessions in four weeks. The 19 patients treated have had squamous cell carcinoma, adenocarcinoma, malignant melanoma, plasmacytoma, epithelioid sarcoma, and undifferentiated carcinoma. After more than 150 hyperthermia sessions, we find: (1) local hyperthermia with microwave alone or in combination with ionizing radiation can be used with excellent normal tissue tolerance provided local tissue temperatures are carefully monitored and controlled; (2) a higher level of heat induction in tumor tissue as compared to surrounding normal tissues; and (3) repeated hyperthermia at 42 to 43.5 C for 45 minutes per session immediately following photon irradiation yields a favorable therapeutic result, occasionally dramatic. Local microwave hyperthermia in combination withradiotherapy offers the possibility of substantial impact on clinical cancer therapy, whether of curative or palliative intent.
- Research Organization:
- Veterans Administration Medical Center, Durham, NC
- OSTI ID:
- 5644680
- Journal Information:
- Cancer; (United States), Vol. 45:4; Conference: 20. annual scientific assembly of the American Society of Therapeutic Radiologists, Los Angeles, CA, USA, 31 Oct 1978
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
HYPERTHERMIA
RADIOSENSITIVITY EFFECTS
SIDE EFFECTS
PATIENTS
TEMPERATURE MEASUREMENT
RADIOTHERAPY
TUMOR CELLS
RADIOSENSITIVITY
COBALT 60
DATA COMPILATION
ELECTRONS
FRACTIONATED IRRADIATION
GAMMA RADIATION
ISOLATED VALUES
LOCAL IRRADIATION
MICROWAVE RADIATION
NEOPLASMS
X RADIATION
ANIMAL CELLS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY TEMPERATURE
COBALT ISOTOPES
DATA
DATA FORMS
DISEASES
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
FERMIONS
INFORMATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LEPTONS
MEDICINE
MINUTES LIVING RADIOISOTOPES
NUCLEAR MEDICINE
NUCLEI
NUMERICAL DATA
ODD-ODD NUCLEI
RADIATIONS
RADIOISOTOPES
RADIOLOGY
THERAPY
YEARS LIVING RADIOISOTOPES
550603* - Medicine- External Radiation in Therapy- (1980-)
560151 - Radiation Effects on Animals- Man