I-123 labeled radiotracers in cardiovascular nuclear medicine
Radiohalogens (particularly /sup 18/F, /SUP 34m/ C1, /sup 77/Br, /sup 75/Br, /sup 123/I, and /sup 125/I and /sup 211/At) produced in a cyclotron are nuclides of choice for radiopharmaceuticals. It has long been recognized that I-123 is the most desirable radioisotope of iodine for in vivo applications. I-123 labeled substrates suitable for imaging the myocardium include receptor binding agents, muscarinic antagonists and analogs of fatty acids. Radioiodinated (I-123) fatty acid analogs have gained significant attention because of the possibility that these might give quantitative information regarding the regional myocardial metabolic activity by noninvasive scintigraphic methods. Incorporation of tellurium hetero into a carbon skeleton or beta methylation of a long chain phenyl fatty acid tends to prolong the retention of radioactivity in the myocardium of experimental animals. It is recognized that the radioiodine needs to be placed on a phenyl ring attached (in the ..omega..-position) to a long chain fatty acid for the in vivo stability of the C-I-bond. Among the methods of radioiodination of ..omega..-phenyl fatty acids, a method developed in our laboratory using an organo-thallium intermediate has been found to be simple, efficient, reproducible, and suitable for routine application.
- Research Organization:
- Dept. of Radiology, The Univ. of Texas Health Science Center, Dallas, TX 75235
- OSTI ID:
- 5606136
- Journal Information:
- IEEE Trans. Nucl. Sci.; (United States), Vol. 30:2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
NUCLEAR MEDICINE
RADIOPHARMACEUTICALS
ASTATINE 211
BROMINE 75
BROMINE 77
CARDIOVASCULAR DISEASES
CHLORINE 34
CYCLOTRONS
FLUORINE 18
IODINE 123
IODINE 125
TRACER TECHNIQUES
ACCELERATORS
ALPHA DECAY RADIOISOTOPES
ASTATINE ISOTOPES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BROMINE ISOTOPES
CHLORINE ISOTOPES
CYCLIC ACCELERATORS
DAYS LIVING RADIOISOTOPES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
FLUORINE ISOTOPES
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MEDICINE
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
RADIOISOTOPES
SECONDS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics