Radiation to regional nodes for rhabdomyosarcoma of the genitourinary tract in children: Is it necessary. A report from the Intergroup Rhabdomyosarcoma Study No. 1 (IRS-1)

Journal Article · Sun Jun 01 00:00:00 EDT 1980 · Cancer (Philadelphia); (United States)

DOI:https://doi.org/10.1002/1097-0142(19800615)45:12<3065::AID-CNCR2820451231>3.0.CO;2-F· OSTI ID:5584900

Tefft, M; Hays, D; Raney, Jr, R B; Lawrence, W; Soule, E; Donaldson, M H; Sutow, W W; Gehan, E

Fifty-eight children with genitourinary rhabdomyosarcoma are reported. Lesions involved the bladder (22), prostate (14), vagina/uterus (6), and paratesticular tissues (16). Fifteen of 58 had positive sampling of regional lymph nodes. Eleven of 15 received radiation to no more than 4500 rad in most cases, and 9 of 11 are disease free. Two of 15 had no radiation and are disease free also. Twenty-three of 58 had negative nodes. Six of 23 had radiation to these nodal areas and 4 of 6 are disease free. Fifteen of 17 patients had no radiation and are disease free also. Sixteen of 20 patients with no node sampling are disease free; 9 of 16 had radiation but 7 of 16 did not. All patients in the study had intensive systemic maintenance chemotherapy. One patient failed in regional nodes despite 4500 rad to these node echelons. We suggest chemotherapy and radiotherapy not to exceed 3500 rad in four weeks, to known residual disease including regions from which positive nodes have been obtained.

• Research Organization: Rhode Island Hospital, Providence
• OSTI ID: 5584900
• Journal Information: Cancer (Philadelphia); (United States), Vol. 45:12
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
LYMPH NODES
EXTERNAL IRRADIATION
RADIOTHERAPY
RECOMMENDATIONS
RHABDOMYOSARCOMAS
BLADDER
CHEMOTHERAPY
CHILDREN
FEMALE GENITALS
MALE GENITALS
PATIENTS
RADIATION DOSES
AGE GROUPS
BODY
DISEASES
DOSES
IRRADIATION
LYMPHATIC SYSTEM
MEDICINE
MYOSARCOMAS
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
RADIOLOGY
SARCOMAS
THERAPY
URINARY TRACT
550603* - Medicine- External Radiation in Therapy- (1980-)
560151 - Radiation Effects on Animals- Man