Augmentation of myocardial ischemia by low level carbon monoxide exposure in dogs

Journal Article · Sun Jul 01 00:00:00 EDT 1979 · Arch. Environ. Health; (United States)

DOI:https://doi.org/10.1080/00039896.1979.10667413· OSTI ID:5557062

Becker, L C ^[1]; Haak, Jr, E D

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1. Johns Hopkins Univ., Baltimore, MD

This study was conducted to determine whether low level exposure to carbon monoxide would increase myocardial ischemia associated with acute myocardial infarction. An hour after coronary artery ligation, eleven anesthetized dogs underwent five sequential respiratory exposures to 5000 ppM carbon monoxide, producing mean blood carboxyhemoglobin levels of 4.9% to 17.0%. Ischemia, as indicated by the amount of S-T segment elevation in epicardial electrocardiograms, increased significantly at the lowest carboxyhemoglobin level and increased further with increasing carbon monoxide exposure. These changes occurred in the absence of altered heart rate, blood pressure, left atrial pressure, cardiac output, or blood flow to ischemic myocardium. Flow to non-ischemic myocardium increased with carbon monoxide exposure, the percentage increase being approximately double the increase in carboxyhemoglobin level. Thus, low level exposure to carbon monoxide can significantly augment ischemia in acute myocardial infarction, apparently through a reduction in oxygen supplied to ischemic tissue. The data suggest that hypoxia induced by carbon monoxide exposure is more severe than can be accounted for by a simple reduction in oxygenated hemoglobin.

• OSTI ID: 5557062
• Journal Information: Arch. Environ. Health; (United States), Vol. 34:4
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
CARBON MONOXIDE
BIOLOGICAL EFFECTS
HEART
DYNAMIC FUNCTION STUDIES
AIR POLLUTION
ANOXIA
BLOOD FLOW
BLOOD PRESSURE
CARBOXYHEMOGLOBIN
CORONARIES
DOGS
ELECTROCARDIOGRAMS
HEMOGLOBIN
INHALATION
ISCHEMIA
MYOCARDIAL INFARCTION
MYOCARDIUM
OXYGEN
ANEMIAS
ANIMALS
ARTERIES
BLOOD VESSELS
BODY
CARBON COMPOUNDS
CARBON OXIDES
CARBOXYLIC ACIDS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CHALCOGENIDES
CRYOGENIC FLUIDS
DIAGRAMS
DISEASES
ELEMENTS
FLUIDS
GLOBIN
HEMIC DISEASES
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
INTAKE
MAMMALS
MUSCLES
NONMETALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
PIGMENTS
POLLUTION
PORPHYRINS
PROTEINS
SYMPTOMS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
551000 - Physiological Systems