Use of I-131 labeled, murine Fab against a high molecular weight antigen of human melanoma: Preliminary experience

Conference · Wed May 01 00:00:00 EDT 1985 · Radiology; (United States)

OSTI ID:5553522

Larson, S M; Carrasquillo, J A; McGuffin, R W; Krohn, K A; Ferens, J M; Hill, L D; Beaumier, P L; Reynolds, J C; Hellstroem, K E; Hellstroem, I

High molecular-weight antigen (HMWA) is tumor-associated proteoglycan of human malignant melanoma. I-131 labeled Fab fragments of these specific antibodies were used for preliminary feasibility studies for radioimmunodetection and therapy of human subjects who had inoperable metastatic melanoma. Ten patients received tracer doses of I-131 (anti-HMWA) Fab. All patients (8/8) who had melanoma lesions greater than 1 cm by correlative diagnosis methods had one or more lesions that had localization to tumor of the radiolabelled Fab. In all, 17 of 23 (74%) documented metastases were seen. Two patients who had avid uptake received potentially radiotherapeutic doses. For both of these patients, whole imaging studies showed that the localization of the high dose I-131 Fab was predominantly in tumor. On whole body images, the anti-Fab HMWA appears to be more tumor selective than Fab preparations that target the p97 antigen for melanoma, and there is less uptake in liver.

• Research Organization: National Institutes of Health, Bethesda, MD
• OSTI ID: 5553522
• Report Number(s): CONF-851152-; TRN: 85-016707
• Journal Information: Radiology; (United States), Vol. 155:2; Conference: 71. scientific assembly and annual meeting, Chicago, IL, USA, 17 Nov 1985
• Country of Publication: United States
• Language: English

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