Evaluation of indium-111-labeled antifibrin monoclonal antibody for the diagnosis of venous thrombotic disease

Journal Article · Wed May 01 00:00:00 EDT 1991 · Journal of Nuclear Medicine; (USA)

OSTI ID:5545903

De Faucal, P; Peltier, P; Planchon, B; Dupas, B; Touze, M D; Baron, D; Scaible, T; Berger, H J; Chatal, J F ^[1]

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1. CHU, Nantes (France)

The potential advantage of using {sup 111}In-antifibrin ({sup 111}In-AF) monoclonal antibody for the diagnosis of deep venous thrombosis (DVT) was studied in 44 patients with suspected DVT (27 underwent heparin therapy before {sup 111}In-AF injection). All patients had contrast venography (considered as the gold standard) and {sup 111}In-AF scintigraphy within 24 hr. Two to 3 mCi of {sup 111}In-AF were injected intravenously, and planar scintigraphy of the limbs was recorded within 10 min (17 times), 3 hr (44 times), and 18 hr (39 times). Indium-111-AF images were then interpreted without knowledge of the results of the other examinations. The DVT diagnostic accuracy of {sup 111}In-AF was greater when interpretation was based on images recorded at different time periods after injection. Indium-111-AF sensitivity for diagnosis of DVT was 85% (29/34) and was not apparently decreased by heparin therapy. None of the 10 patients with negative contrast venography had a positive {sup 111}In-AF scan. The results demonstrate the importance of recording serial images and the excellent accuracy of {sup 111}In-AF for diagnosing DVT.

• OSTI ID: 5545903
• Journal Information: Journal of Nuclear Medicine; (USA), Vol. 32:5; ISSN 0161-5505
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
LIMBS
RADIOIMMUNOSCINTIGRAPHY
MONOCLONAL ANTIBODIES
EVALUATION
THROMBOSIS
DIAGNOSIS
ACCURACY
CONTRAST MEDIA
INDIUM 111
PATIENTS
ANTIBODIES
BETA DECAY RADIOISOTOPES
BODY
BODY AREAS
CARDIOVASCULAR DISEASES
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
RADIOIMMUNODETECTION
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
TRACER TECHNIQUES
VASCULAR DISEASES
550601* - Medicine- Unsealed Radionuclides in Diagnostics