Hematologic effects in mice exposed to pulsed and cw microwaves. Annual report
Mice were exposed in the far field of an anechoic chamber to 2880-MHz pulsed microwaves (2.3-microsec pulses, 100/sec) 3-7.5 hr daily for 60-360 hr. In two of five studies with 5-mW/sq cm pulsed microwaves there was a significant increase in bone marrow cellularity compared to the sham-exposed groups, but in the other three exposures at 5-mW/sq cm no significant effect was observed. Significant differences were occasionally seen in erythrocyte, leukocyte and platelet measurements from microwave-exposed groups, but were not consistently observed. The only effect seen in mice exposed to 5-mW/sq cm CW microwaves was a reduction in reticulocyte concentrations (P less than 0.02). In one of four exposures at 10-mW/sq cm pulsed microwaves, mean bone marrow cellularity was reduced (P less than 0.02) in the microwave-exposed mice, and in another group the concentration of circulating lymphocytes was increased (P less than 0.05). In only one exposure (10-mW/sq cm for 360 hr) was any effect noted on serum proteins: a reduction (P less than 0.02) to 5.1 + or - 0.29 g/dl in the exposed vs 5.6 + or - 0.36 g/dl in the sham-exposed mice. This was due to a decrease in alpha and beta-globulins, with no effect on albumin or gamma-globulin concentrations. No effect on bone marrow hematopoietic colony-forming units (CFU) was revealed by CFU-agar assay techniques following exposure of mice to 5-mW/sq cm pulsed microwaves. In 1 of 4 exposures of mice to 10-mW/sq cm pulsed microwaves there was a significant (P less than 0.05) increase in CFU-agar colonies.
- Research Organization:
- Battelle Pacific Northwest Labs., Richland, WA (USA)
- DOE Contract Number:
- N00014-76-C-1154
- OSTI ID:
- 5544078
- Report Number(s):
- AD-A-065326
- Country of Publication:
- United States
- Language:
- English
Similar Records
Hematologic and immunologic effects of pulsed microwaves in mice
Hematotoxicity and carcinogenicity of inhaled benzene
Related Subjects
59 BASIC BIOLOGICAL SCIENCES
BLOOD CELLS
PATHOLOGICAL CHANGES
BONE MARROW
CFU
GLOBULINS
MICROWAVE RADIATION
BIOLOGICAL EFFECTS
CHRONIC IRRADIATION
MICE
PULSED IRRADIATION
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
CHRONIC EXPOSURE
DISEASES
ELECTROMAGNETIC RADIATION
HEMATOPOIETIC SYSTEM
IRRADIATION
MAMMALS
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIATIONS
RODENTS
TISSUES
VERTEBRATES
560400* - Other Environmental Pollutant Effects
550200 - Biochemistry
551000 - Physiological Systems