Great Lakes fish consumption and reproductive outcomes
This epidemiological investigation determined prenatal exposure to polychlorinated biphenyls (PCBs), through contaminated fish consumption, and ascertained reproductive outcomes. Green Bay, Wisconsin was chosen as the study site because it was known for its environmental contamination of PCBs. These chemicals are environmentally stable and persistent, and tend to bioaccumulate up the food chain, with highest levels found in predatory sport fish from Lake Michigan. The Green Bay area provided a population with potential PCB exposure from sport fish consumption. Accidental poisoning incidents showed detrimental reproductive effects of high dose PCB exposures. A Michigan study found significant effects on birth weight and gestational age when mothers consumed two sport fish meals per month. This study population was drawn from women during their first prenatal visit at two Green Bay clinics during a one year period. 1,112 participants completed a self-administered questionnaire. Maternal and cord blood samples were obtained for selected PCB serum analyses. Reproductive outcome measures were abstracted from hospital labor reports. Study results indicated that maternal consumption was correlated to maternal PCB serum levels. Regression techniques estimated significant exposure coefficients for subsets of two birth size parameters. Birth length was positively associated with PCB exposure in shorter mothers. Significant associations of PCB exposure and birth weight percentiles were estimated for two income groups in the urban residence/weight gain less than 34 pounds subset.
- Research Organization:
- Wisconsin Univ., Madison, WI (United States)
- OSTI ID:
- 5542844
- Resource Relation:
- Other Information: Thesis (Ph. D.)
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
54 ENVIRONMENTAL SCIENCES
CHLORINATED AROMATIC HYDROCARBONS
TOXICITY
FISHES
CONTAMINATION
GREAT LAKES
WATER POLLUTION
REPRODUCTIVE DISORDERS
EPIDEMIOLOGY
WISCONSIN
WOMEN
ANIMALS
AQUATIC ORGANISMS
AROMATICS
DEVELOPED COUNTRIES
FEDERAL REGION V
FEMALES
HALOGENATED AROMATIC HYDROCARBONS
LAKES
MAMMALS
MAN
NORTH AMERICA
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
POLLUTION
PRIMATES
SURFACE WATERS
USA
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology
540320 - Environment
Aquatic- Chemicals Monitoring & Transport- (1990-)