/sup 125/I Vicryl suture implants as a surgical adjuvant in cancer of the head and neck
Sixty-four intraoperative /sup 125/I seed implants using absorbable suture (Vicryl) carriers were performed in 53 patients with head and neck cancers at Stanford between 1975 and 1980. In previously untreated patients, local control in the implanted volume or in all head and neck sites was obtained in 79 and 71%, respectively. Of 34 patients with recurrent carcinomas, local control was obtained in the implant volume in 20 (59%), while 38% had no recurrence post-implantation in any head and neck site. The incidence of complications is correlated with /sup 125/I radiation doses, total millicuries inserted, seed strength used, and tissue volume implanted for both untreated patients and those with local recurrences. Guidelines for the optimal use of the above 4 parameters are also presented. The authors conclude that /sup 125/I seed Vicryl intraoperative suture implants are an effective surgical adjuvant in the treatment of advanced, previously untreated or recurrent head and neck cancers.
- Research Organization:
- Stanford Univ. Medical Center, CA
- OSTI ID:
- 5519771
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 11:2
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
CARCINOMAS
RADIOTHERAPY
SIDE EFFECTS
BIOLOGICAL RADIATION EFFECTS
HEAD
IODINE 125
JAW
NECK
OSTEORADIONECROSIS
PATIENTS
RADIATION DOSES
RADIATION SOURCE IMPLANTS
RADIOINDUCTION
SURGERY
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BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
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DAYS LIVING RADIOISOTOPES
DISEASES
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INJURIES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
LOCAL RADIATION EFFECTS
MATERIALS
MEDICAL SUPPLIES
MEDICINE
NECROSIS
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
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PATHOLOGICAL CHANGES
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RADIATION INJURIES
RADIATION SOURCES
RADIOISOTOPES
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SKELETON
SKULL
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560161 - Radionuclide Effects
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