Radiation therapy of head and neck tumors: a randomized study of treatment in air vs treatment in hyperbaric oxygen
A randomized study of squamous cell carcinoma of the head and neck, with the exception of T/sub 1/ vocal cord lesions, compared 23 patients who were treated in air with doses of 250 rad four times a week to 6250 rad, to 21 patients who were treated at three atmospheres of hyperbaric oxygen with 12 x 400-rad fractions in approximately 32 days. Distribution by anatomic site and age was comparable. Distribution by stage was in favor of the air group since five Stage I patients were found in the air group but none in the hyperbaric oxygen group. The sex distribution was uneven - 15 males to eight females in the air group and eight males to 13 females in the oxygen group. All patients were followed for a minimum of two years; most patients were followed more than five years, with indefinite followup. The 12 x 400-rad schedule in four and one-half weeks in the hyperbaric oxygen group proved to be well tolerated without any significant increase in complications. Radiation myelitis can be avoided by limiting the spinal cord dose to 7 x 400 rad.
- Research Organization:
- LDS Hospital, Salt Lake City, UT
- OSTI ID:
- 5511743
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 5:10; Conference: National meeting of the American Society of Therapeutic Radiologists, Los Angeles, CA, USA, 3 Nov 1978
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
AIR
RADIOSENSITIVITY EFFECTS
EDEMA
RADIOINDUCTION
FIBROSIS
HEAD
BIOLOGICAL RADIATION EFFECTS
NECK
OSTEORADIONECROSIS
OXYGEN
ULCERS
COMPARATIVE EVALUATIONS
FRACTIONATED IRRADIATION
NEOPLASMS
PATIENTS
RADIATION DOSES
SIDE EFFECTS
BIOLOGICAL EFFECTS
BODY
BODY AREAS
CRYOGENIC FLUIDS
DISEASES
DOSES
ELEMENTS
FLUIDS
GASES
INJURIES
IRRADIATION
LOCAL RADIATION EFFECTS
NECROSIS
NONMETALS
PATHOLOGICAL CHANGES
RADIATION EFFECTS
RADIATION INJURIES
SKELETAL DISEASES
SYMPTOMS
560151* - Radiation Effects on Animals- Man
550603 - Medicine- External Radiation in Therapy- (1980-)