Airway hyperirritability induced by ozone. Final report, 1977-1978
A study of 14 healthy adult subjects was undertaken to determine whether brief exposure to 0.5-0.6 ppM of ozone would increase bronchial reactivity to inhaled irritants, as reflected by the rise in airway resistance provoked by aerosol challenge with weak solutions of histamine or methacholine. An additional study of 9 subjects with nonasthmatic allergic diseases was also undertaken to determine the effects on ozone on bronchial reactivity in atopic subjects. Subjects from both the non-atopic groups were exposed to ozone on several occasions to determine whether tolerance develops to the sensitizing effects of ozone on bronchial responsiveness. The results indicate that exposure to 0.6 ppM of ozone for 2 hours increases bronchial reactivity to histamine in both normal and atopic subjects and that the increase in responsiveness is blocked by pretreatment with atropine, suggesting that postganglionic cholinergic mechanisms are involved. Bronchial reactivity returned to control levels in 1-7 days in most subjects, but tolerance to repeated exposures to ozone was not observed.
- Research Organization:
- California Univ., San Francisco (USA). School of Medicine; California State Air Resources Board, Sacramento (USA)
- OSTI ID:
- 5499036
- Report Number(s):
- PB-82-113234
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
54 ENVIRONMENTAL SCIENCES
OZONE
ADULTS
AIR POLLUTION
ALLERGY
BRONCHI
CHRONIC EXPOSURE
HISTAMINE
REACTIVITY
RESPIRATORY SYSTEM
TOLERANCE
TOXICITY
AGE GROUPS
AMINES
AZOLES
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PATHOLOGICAL CHANGES
POLLUTION
560306* - Chemicals Metabolism & Toxicology- Man- (-1987)
500200 - Environment
Atmospheric- Chemicals Monitoring & Transport- (-1989)