Cigarette smoke inhalation decreases. cap alpha. /sub 1/-antitrypsin activity in rat lung

Journal Article · Fri Dec 14 00:00:00 EST 1979 · Science; (United States)

OSTI ID:5486638

Janoff, A ^[1]; Carp, H; Lee, D K; Drew, R T

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1. State Univ. of New York, Stony Brook

Brief inhalation exposure of rats to three or six puffs of cigarette smoke significantly decreases elastase inhibitory capacity per milligram of ..cap alpha../sub 1/-antitrypsin in lung lavage fluid. This effect is not observed in ozone-tolerant rats and can be reversed by treating the lung lavage fluid from smoke-exposed rats with reducing agents. Samples of human serum obtained immediately after smoking also show decreased elastase inhibitory capacity per milligram of ..cap alpha../sub 1/-antitrypsin. Again, elastase inhibitory capacity can be restored by treatment with a reducing agent. Cigarette smoking may cause emphysema by inactivating ..cap alpha../sub 1/-antitrypsin through oxidation.

• DOE Contract Number: EY-76-C-02-0016
• OSTI ID: 5486638
• Journal Information: Science; (United States), Vol. 206
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
TOBACCO SMOKES
HEALTH HAZARDS
EMPHYSEMA
ENZYMES
INHALATION
LAVAGE
LUNGS
MAN
OXIDIZERS
OZONE
RATS
REDUCING AGENTS
AEROSOLS
ANIMALS
BODY
COLLOIDS
DISEASES
DISPERSIONS
HAZARDS
INTAKE
MAMMALS
ORGANS
PRIMATES
RESIDUES
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
RODENTS
SMOKES
SOLS
VERTEBRATES
560306* - Chemicals Metabolism & Toxicology- Man- (-1987)
550200 - Biochemistry