Nanodosimetry and nanodosimetric-based models of radiation action for radon alpha particles

Technical Report · Wed Jan 01 00:00:00 EST 1992

DOI:https://doi.org/10.2172/5482511· OSTI ID:5482511

The objective of our research work is to provide -- with the aid of biophysical models of radiation action -- information on human risks following exposure to radon alpha particles. The approach proposed consists of (1) developing appropriate models (parametric and non-parametric) for alpha radiation induction of relevant end points (survival, cellular transformation), (2) providing an accurate physical characterization of the particle tracks in terms of nanodosimetric distributions, (3) supporting the models by detailed, molecular studies of the direct and indirect effects of alpha particles on DNA. Activities in the second year of this project are described.

• Research Organization: Columbia Univ., New York, NY (United States)
• Sponsoring Organization: USDOE; USDOE, Washington, DC (United States)
• DOE Contract Number: FG02-90ER61022
• OSTI ID: 5482511
• Report Number(s): DOE/ER/61022-2; ON: DE92010798
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
DNA
BIOLOGICAL RADIATION EFFECTS
ALPHA PARTICLES
DOSIMETRY
PROGRESS REPORT
RADON
STRAND BREAKS
BIOLOGICAL EFFECTS
CHARGED PARTICLES
DOCUMENT TYPES
ELEMENTS
FLUIDS
GASES
NONMETALS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
RADIATION EFFECTS
RARE GASES
560120* - Radiation Effects on Biochemicals
Cells
& Tissue Culture