Regional myocardial blood flow distribution during intracoronary infusion of parathyroid hormone

Conference · Sat Mar 01 00:00:00 EST 1986 · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)

OSTI ID:5458926

Crass, III, M F; Lust, R M

Although low doses of the biologically-active fragment of parathyroid hormone PTH-(1-34), have been shown to produce potent dilation of the coronary circulation specific regional and transmural (endo/epi) myocardial blood flow (MBF) responses to the hormone have not been described. Anesthetized open-chest mongrel dogs were instrumented to quantitate coronary blood flow and other cardiodynamic parameters. PTH-(1-34) was infused into the left circumflex artery (.008 nmol kg/sup -1/ min/sup -1/). Using the reference withdrawal method, radionuclide-labeled microspheres were injected before (basal flow), during (8 min after new steady-state flow), and after (restoration of basal flow) a 20 min infusion of PTH-(1-34). MFB increased from 76 +- 1.9 to 152 +- 3.5 ml min/sup -1/ 100 g/sup -1/ (P < .001) during PTH-(1-34) infusion. No differences in endo/epi flow ratio or regional coronary blood flow within the left ventricle were detected. Thus, in anesthetized dogs, the increase in MBF observed secondary to the PTH-(1-34)-induced decrease in coronary resistance appeared to be uniform transmurally and regionally, and is probably not the result of a shunting or steal phenomenon.

• Research Organization: Texas Tech Univ. Health Sciences Center, Lubbock
• OSTI ID: 5458926
• Report Number(s): CONF-8604222-; TRN: 86-028542
• Journal Information: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States), Vol. 45:3; Conference: 70. annual meeting of the Federation of American Society for Experimental Biology, St. Louis, MO, USA, 13 Apr 1986
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
MYOCARDIUM
BLOOD FLOW
PARATHORMONE
INFUSION
BLOOD CIRCULATION
CORONARIES
DOGS
MICROSPHERES
RADIOISOTOPES
TRACER TECHNIQUES
ANIMALS
ARTERIES
BLOOD VESSELS
BODY
CARDIOVASCULAR SYSTEM
HEART
HORMONES
INTAKE
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MUSCLES
ORGANS
PEPTIDE HORMONES
VERTEBRATES
551001* - Physiological Systems- Tracer Techniques