A technique for the preparation of Tc-99m red blood cells for evaluation of gastrointestinal hemorrhage

Journal Article · Fri Apr 01 00:00:00 EST 1983 · Clin. Nucl. Med.; (United States)

DOI:https://doi.org/10.1097/00003072-198304000-00004· OSTI ID:5442217

Benedetto, A R; Nusynowitz, M L

Tc-99m labeled red blood cell (RBC) preparations are gaining wide acceptance in the diagnosis and localization of gastrointestinal bleeding. A major requirement of the radiopharmaceutical is that the percentage of Tc-99m attached to red cells in the injected dose must be extremely high, since free pertechnetate is secreted into the gastrointestinal tract and may obscure a bleeding site. We have developed a combined in vivo/in vitro labeling procedure which is simple and rapid, and which enables the administration of substantial amounts of RBC-bound Tc-99m and minimizes the amount of unbound technetium present. The technique is readily utilizable in any nuclear medicine clinic and requires no investigative pharmaceuticals.

• Research Organization: Department of Radiology, University of Texas Health Science Center, San Antonio
• OSTI ID: 5442217
• Journal Information: Clin. Nucl. Med.; (United States), Vol. 8:4
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ERYTHROCYTES
LABELLING
HEMORRHAGE
DIAGNOSIS
TECHNETIUM 99
DIAGNOSTIC USES
DIGESTIVE SYSTEM DISEASES
GASTROINTESTINAL TRACT
RADIOPHARMACEUTICALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
DIGESTIVE SYSTEM
DISEASES
DRUGS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MATERIALS
NUCLEI
ODD-EVEN NUCLEI
PATHOLOGICAL CHANGES
RADIOISOTOPES
SYMPTOMS
TECHNETIUM ISOTOPES
USES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics