Effects of cardiac sympathetic nerve stimulation on regional coronary blood flow
The purpose of this study was to examine the effects of cardiac sympathetic nerve stimulation on regional coronary blood flow following ..beta..-blockade. In 17 anesthetized dogs treated with propranolol (2 mg/kg iv) regional myocardial perfusion was measured (radio labelled microspheres) during control and during stimulation of the ventrolateral, ventromedial, or recurrent cardiac nerve. Ventrolateral nerve stimulation produced 25.5 +/- 3.4 and 23.5 +/- 3.1% (mean +/- SE) decreases in coronary blood flow in the posterior and lateral quadrants of the left ventricle. Ventromedial nerve stimulation produced 18.6 +/- 2.8, 15.4 +/- 2.8, and 10.1 +/- 3.2% decreases in flow in the anterior, septal, and lateral left ventricle, respectively. Recurrent cardiac nerve stimulation produced 16.4 +/- 2.1, 15.6 +/- 2.2, and 13.6 +/- 2.5% decreases in flow in the anterior and septal left ventricle and right ventricle, respectively. Ventrolateral nerve stimulation resulted in a small but significant increase in the endocardial-to-epicardial blood flow ratio in the posterolateral left ventricle. The authors conclude that the cardiac sympathetic nerves have selective regional effects on myocardial perfusion that could contribute to fine regulation of flow in the normal heart and could have beneficial or adverse effects in the setting of coronary stenosis or occlusion.
- Research Organization:
- Univ. of Utah School of Medicine, Salt Lake City
- OSTI ID:
- 5434839
- Journal Information:
- Am. J. Physiol.; (United States), Vol. 252:2
- Country of Publication:
- United States
- Language:
- English
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BLOOD FLOW
DYNAMIC FUNCTION STUDIES
LABELLED COMPOUNDS
TRACER TECHNIQUES
CADMIUM 109
CERIUM 141
CHROMIUM 51
COBALT 57
DOGS
GADOLINIUM 153
HEART
INDIUM 114
IRON 59
MICROSPHERES
NERVES
NIOBIUM 95
PERFUSED TISSUES
PHYSIOLOGY
RUTHENIUM 103
STIMULATION
STRONTIUM 85
TIN 113
ZINC 65
ALKALINE EARTH ISOTOPES
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CADMIUM ISOTOPES
CARDIOVASCULAR SYSTEM
CERIUM ISOTOPES
CHROMIUM ISOTOPES
COBALT ISOTOPES
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
GADOLINIUM ISOTOPES
HOURS LIVING RADIOISOTOPES
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IRON ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MINUTES LIVING RADIOISOTOPES
NERVOUS SYSTEM
NIOBIUM ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANS
RADIOISOTOPES
RARE EARTH ISOTOPES
RARE EARTH NUCLEI
RUTHENIUM ISOTOPES
SECONDS LIVING RADIOISOTOPES
STRONTIUM ISOTOPES
TIN ISOTOPES
TISSUES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
ZINC ISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics