Inverse relationship between cardiac accumulation of meta-(/sup 131/I)iodobenzylguanidine (I-131 MIBG) and circulation catecholamines in suspected pheochromocytoma
Heart intensity (HI) in the 24- and 48-hr images of meta-(/sup 131/I)iodobenzylguanidine (I-131 MIBG), a pheochromocytoma-seeking guanethidine analog, were compared with concentrations of plasma and urinary catecholamines and their metabolites in nonpheochromocytoma and pheochromocytoma patients. HI was inversely related to plasma concentrations and urinary excretion rates of the hormones. Plasma norepinephrine had the highest inverse correlation with HI (r = -0.73 at 24 hr, -0.63 at 48 hr) and urinary metanephrine the lowest (r = -0.23 at 24 hr, -0.28 at 48 hr). A similar relationship was observed in the intensity of salivary-gland visualization, but with less marked variations. HI was much higher in ninpheochromocytoma patients than in pheochromocytoma patients. HI in an I-131 MIGB image provides useful information in the diagnosis of pheochromocytoma, and may provide a tool for the study of the influence of catecholamines on the heart.
- Research Organization:
- Univ. of Michigan, Ann Arbor
- OSTI ID:
- 5432880
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 24:12
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
CATECHOLAMINES
BIOCHEMISTRY
HEART
SCINTISCANNING
IODINE 131
NEOPLASMS
DIAGNOSIS
BLOOD PLASMA
EXPERIMENTAL DATA
GUANIDINES
PATIENTS
URINE
AMINES
AROMATICS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLOOD
BODY
BODY FLUIDS
CARBONIC ACID DERIVATIVES
CARDIOVASCULAR SYSTEM
CHEMISTRY
COUNTING TECHNIQUES
DATA
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
HYDROXY COMPOUNDS
INFORMATION
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
MATERIALS
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PHENOLS
POLYPHENOLS
RADIOISOTOPE SCANNING
RADIOISOTOPES
WASTES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
550200 - Biochemistry