Diethylstilbestrol-diphosphate induces chromosomal aberrations but not sister chromatid exchanges in murine bone marrow cells in vivo

Journal Article · Thu Jan 01 00:00:00 EST 1981 · Environ. Mutagen.; (United States)

DOI:https://doi.org/10.1002/em.2860030405· OSTI ID:5406346

Ivett, J L ^[1]; Tice, R R

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1. North Carolina State Univ., Raleigh

Diethylstilbestrol diphosphate (DES-dp) clastogenesis was examined in the bone marrow of C57B1/6 male and female mice. Significant and sex-related dose effects were observed for the induction of chromatid-type chromosomal aberrations and for the inhibition of cellular proliferation. Females were more sensitive to the effects of DES-dp than males when assessed for either induced chromosomal aberrations or proliferative inhibition. Contrary to other published results, we did not observe either an increase in sister chromatid exchanges or an increased incidence of aneuploidy. Ovariectomy reduced the ability of DES-dp to inhibit cellular proliferation and decreased the high degree of variability between animals at high doses of DES-dp. The results of our studies show that DES is a clastogenic agent in vivo which may relate to its carcinogenicity.

• DOE Contract Number: AC02-76CH00016
• OSTI ID: 5406346
• Journal Information: Environ. Mutagen.; (United States), Vol. 3
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
CELL PROLIFERATION
INHIBITION
ESTROGENS
BIOLOGICAL EFFECTS
BONE MARROW CELLS
CHROMOSOMAL ABERRATIONS
DOSE-RESPONSE RELATIONSHIPS
IN VIVO
MICE
SEX DEPENDENCE
ANIMAL CELLS
ANIMALS
CONNECTIVE TISSUE CELLS
HORMONES
MAMMALS
MUTATIONS
RODENTS
SOMATIC CELLS
STEROID HORMONES
VERTEBRATES
550400* - Genetics