Distribution and dosimetry of /sup 111/In-labeled platelets
The distribution of /sup 111/In-labeled platelets was studied in five young, healthy men. The radioactivity in the lungs, heart, liver, spleen, kidneys, and testes was determined from areas-of-interest in computed gamma-camera scans at intervals up to 75 hours after injection. After the first four hours, the activity in each organ studied except the liver and kidney decreased at roughly the physical decay rate. In the liver and kidney, the curves were relatively flat, indicating continued accumulation of the radiotracer. The calculated mean radiation absorbed dose per unit administered activity was 0.60 +/- 0.07 rad/mCi (0.16 +/- 0.02 Gy/GBq) for the total body, and was 34 +/- 6 rad/mCi (9.0 +/- 1.5 Gy/GBq) for the spleen.
- OSTI ID:
- 5405496
- Journal Information:
- Radiology; (United States), Vol. 140:1
- Country of Publication:
- United States
- Language:
- English
Similar Records
Distribution and dosimetry of In-111 labeled leukocytes and platelets in humans
Primary lung cancer: Biodistribution and dosimetry of two In-111-labeled monoclonal antibodies
Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
INDIUM 111
DIAGNOSTIC USES
RADIONUCLIDE KINETICS
BIOLOGICAL LOCALIZATION
BLOOD PLATELETS
COMPARATIVE EVALUATIONS
GAMMA CAMERAS
GAMMA DOSIMETRY
HEART
KIDNEYS
LIVER
LUNGS
MALES
PATIENTS
RADIATION DOSES
SCINTISCANNING
SPLEEN
TESTES
TIME DEPENDENCE
TISSUE DISTRIBUTION
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CAMERAS
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISTRIBUTION
DOSES
DOSIMETRY
ELECTRON CAPTURE RADIOISOTOPES
GLANDS
GONADS
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MALE GENITALS
MATERIALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RESPIRATORY SYSTEM
USES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
560172 - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)