Evaluation of mutagenic activities of endosulfan phosalone, malathion, and permethrin, before and after metabolic activation, in the Ames Salmonella test

Journal Article · Mon Jun 01 00:00:00 EDT 1987 · Bull. Environ. Contam. Toxicol.; (United States)

DOI:https://doi.org/10.1007/BF01609074· OSTI ID:5393794

Pednekar, M D; Gandhi, S R; Netrawali, M S

The work reported here evaluates the mutagenic activities of commonly used insecticides - endosulfan (organochlorine), phosalone and malathion (organophosphorus) and permethrin (pyrethroid), before and after activation with cecal microbial extract or with liver post-mitochondrial fraction (S9-fraction) of rat, in Ames test with Salmonella typhimurium tester strains TA 97a, TA 98 and TA 100. As far as we are aware, no study has yet addressed whether the insecticides mentioned above can be mutagenic following their activation by mammalian cecal microorganisms.

• Research Organization: Bhabha Atomic Research, Bombay, India
• OSTI ID: 5393794
• Journal Information: Bull. Environ. Contam. Toxicol.; (United States), Vol. 38:6
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CHLORINATED AROMATIC HYDROCARBONS
METABOLIC ACTIVATION
MUTAGEN SCREENING
INSECTICIDES
LIVER
MALATHION
ORGANIC PHOSPHORUS COMPOUNDS
RATS
SALMONELLA TYPHIMURIUM
ANIMALS
AROMATICS
BACTERIA
BODY
CARBOXYLIC ACID ESTERS
DIGESTIVE SYSTEM
ESTERS
GLANDS
HALOGENATED AROMATIC HYDROCARBONS
MAMMALS
MICROORGANISMS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PESTICIDES
RODENTS
SALMONELLA
SCREENING
THIOLS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology