Circadian stage dependence in radiation: response of dividing cells in vivo

Journal Article · Thu Jan 01 00:00:00 EST 1981 · Prog. Clin. Biol. Res.; (United States)

OSTI ID:5388202

Rubin, N H

1) When the mouse corneal epithelium wa irradiated with one dose or ionizing radiation, the effect on mitosis varied depending upon the time in the 24-h period when it was irradiated. 2) Release of the radiation-induced mitotic block, as measured by appearance of a recovery wave of mitotic cells, occurred only during the daily increase in mitotic index in the control animals. 3) The entire wave of recovery occurred within the same time as the controls, and no rebound was seen. 4) Mitotic delay was dose-dependent. 5) The results of these experiments emphasize the importance of considering the circadian system when studying cell division in vivo.

• OSTI ID: 5388202
• Journal Information: Prog. Clin. Biol. Res.; (United States), Vol. 59C:00
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
EPITHELIUM
BIOLOGICAL RADIATION EFFECTS
MITOTIC INDEX
RADIOSENSITIVITY EFFECTS
CELL CYCLE
DAILY VARIATIONS
DOSE-RESPONSE RELATIONSHIPS
IN VIVO
MICE
MITOSIS
MITOTIC DELAY
RADIATION DOSES
TIME DEPENDENCE
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BODY
CELL DIVISION
DOSES
MAMMALS
RADIATION EFFECTS
RODENTS
TISSUES
VARIATIONS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals
550300 - Cytology