External assessment of myocardial metabolism with C-11 palmitate in vivo
The externally detected rate of clearance of C-11 palmitate ((/sup 11/C)palmitic acid) from isolated hearts varies directly with CO/sub 2/ production from neutral lipids and with physiological indexes of myocardial oxygen consumption. The present study was performed to determine whether myocardial metabolism could be quantified noninvasively in vivo in a fashion analogous to that in the isolated heart. Opened chest, male rabbits were injected with C-11 Palmitate (100 to 200 ..mu..Ci) and coincidence counts were detected externally with two NaI(Tl) crystals so placed that their colinear field of view encompassed the heart. The monoexponential rate of clearance of tracer - obtained from the portion of the residue-detection curve reflecting metabolism of fatty acid incorporated into neutral lipids - correlated direction with induced changes in tension-time index after injections into the left atrium (r = 0.96, n = 12), right atrium (r = 0.86, n = 14), and ear vein (r = 0.93, n = 14). Clearance of labeled palmitate from the vascular pool within the field of detection (determined with both C-14 palmitate and red blood cells labeled with C/sup 15/O-hemoglobin) was rapid and did not significantly affect measurements of palmitate clearance from the heart itself.
- Research Organization:
- Washington Univ. School of Medicine, St. Louis, MO
- OSTI ID:
- 5340246
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 21:4
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
CARBON COMPOUNDS
CLEARANCE
HEART
RADIONUCLIDE KINETICS
MYOCARDIUM
METABOLISM
CARBON 11
CARBON DIOXIDE
ERYTHROCYTES
EXPERIMENTAL DATA
GRAPHS
HEMOGLOBIN
HEXADECANOIC ACID
LIPIDS
OXYGEN
RABBITS
RADIATION DETECTORS
TIME DEPENDENCE
TRACER TECHNIQUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CARBON ISOTOPES
CARBON OXIDES
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
CHALCOGENIDES
CRYOGENIC FLUIDS
DATA
DATA FORMS
ELEMENTS
EVEN-ODD NUCLEI
FLUIDS
GLOBIN
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
INFORMATION
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
MAMMALS
MATERIALS
MEASURING INSTRUMENTS
MINUTES LIVING RADIOISOTOPES
MONOCARBOXYLIC ACIDS
MUSCLES
NONMETALS
NUCLEI
NUMERICAL DATA
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
PIGMENTS
PORPHYRINS
PROTEINS
RADIOISOTOPES
VERTEBRATES
560172* - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)
551001 - Physiological Systems- Tracer Techniques