Functional hyposplenia after splenic irradiation for Hodgkin's disease

Journal Article · Fri Jan 01 00:00:00 EST 1982 · Ann. Intern. Med.; (United States)

DOI:https://doi.org/10.7326/0003-4819-96-1-44· OSTI ID:5338013

Coleman, C N; McDougall, I R; Dailey, M O; Ager, P; Bush, S; Kaplan, H S

We previously reported a patients who developed fulminant pneumococcal sepsis 12 years after successful treatment for Hodgkin's disease, which included splenic irradiation. We have since evaluated splenic size and function in 25 patients who had received splenic irradiation 5 to 16 years previously either for Hodgkin's disease (n . 19) or non-Hodgkin's lymphoma (n . 6). Mean maximum splenic diameter as measured on a 99mTc-sulfur colloid liver-spleen scan was 6.2 cm in the irradiated group and 9.7 cm in a control group (p less than 0.001). The mean percentage of erythrocytes containing pits when observed with interference phase microscopy was 13.0% in the irradiated group, which was significantly different (p less than 0.001) from the levels found in each of the control groups: normal subjects, 0.9%; unstaged and untreated lymphoma patients, 0.6%; and patients after splenectomy, 33.7%. Patients who have had splenic irradiation should be considered at risk of developing overwhelming pneumococcal sepsis.

• Research Organization: Division of Radiation Therapy, Department of Radiology, Stanford, California
• OSTI ID: 5338013
• Journal Information: Ann. Intern. Med.; (United States), Vol. 96:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
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HODGKINS DISEASE
RADIOTHERAPY
SPLEEN
DELAYED RADIATION EFFECTS
ERYTHROCYTES
INFECTIVITY
ISOMERIC NUCLEI
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RADIOISOTOPE SCANNING
SIZE
TECHNETIUM 99
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BETA DECAY RADIOISOTOPES
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BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
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BLOOD CELLS
BODY
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COUNTING TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
GLANDS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
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ISOTOPES
MATERIALS
MEDICINE
MICROORGANISMS
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NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIATION EFFECTS
RADIOISOTOPES
RADIOLOGY
TECHNETIUM ISOTOPES
THERAPY
YEARS LIVING RADIOISOTOPES
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