Neurotoxic metabolites of ''commercial hexane'' in the urine of shoe factory workers
Urinary metabolites were tested in 41 shoe-factory workers exposed to a mixture of 10 solvents among which ''commercial hexane'' was the prevailing component. Cyclohexanol, 2-methyl-2-pentanol, 3-methyl-2-pentanol, and trichloroethanol were determined in connection with exposure to cyclohexane, 2-methylpentane, 3-methylpentane, and trichloroethylene, respectively. 2-Hexanol, 2,5-hexanedione, 2,5-dimethylfuran, and gamma-valerolactone were all determined in connection with n-hexane exposure only. 2,5-Hexanedione was the principal n-hexane metabolite found in the workers' urine. This finding of the experimentally proven neurotoxin 2,5-hexanedione in the urine of shoe-factory workers exposed to ''commercial hexane'' is consistent with the idea that this compound is responsible for the development of neuropathy in this group of individuals.
- Research Organization:
- Institute of Occupational Medicine, University of Padua-Verona, Italy
- OSTI ID:
- 5335840
- Journal Information:
- Clin. Toxicol.; (United States), Vol. 18:12
- Country of Publication:
- United States
- Language:
- English
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NERVOUS SYSTEM DISEASES
EPIDEMIOLOGY
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HEXANE
MANUFACTURERS
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PERSONNEL
TEXTILES
URINE
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
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560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)