Administration of N-nitrosodimethylamine, N-nitrosopyrrolidine, or N'-nitrosonornicotine to nursing rats: their interactions with liver and kidney nucleic acids from sucklings

Journal Article · Sun Jun 01 00:00:00 EDT 1986 · J. Natl. Cancer Inst.; (United States)

OSTI ID:5324748

Diaz Gomez, M I; Tamayo, D; Castro, J A

When nursing Sprague-Dawley rats were treated with (/sup 14/C)N-nitrosodimethylamine ((NDMA) CAS: 62-75-9), N-nitrosopyrrolidine (CAS:930-55-2), or N'-nitrosonornicotine (CAS: 16543-55-8), the liver and kidney DNA from their 14-day-old offspring that had been nursed over a 24-hour period became labeled. Upon analysis, liver DNA from sucklings whose nursing mothers were treated with (/sup 14/C)NDMA showed N7-methylguanine- and O6-methylguanine-altered bases. The results suggest that these nitrosamines, which are present in food, tobacco smoke, and in different environmental sources, are a risk not only for lactating mothers but also for the nursing infants.

• Research Organization: Centro de Investigaciones Toxiocologicas, Buenos Aires, Argentina
• OSTI ID: 5324748
• Journal Information: J. Natl. Cancer Inst.; (United States), Vol. 6
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
NEONATES
CONTAMINATION
NITROSAMINES
UPTAKE
ALKYLATION
CARBON 14 COMPOUNDS
DNA
LIVER
MAMMARY GLANDS
MILK
NUCLEIC ACIDS
RATS
RNA
TRACER TECHNIQUES
AMINES
ANIMALS
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
CHEMICAL REACTIONS
DIGESTIVE SYSTEM
FOOD
GLANDS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MATERIALS
NITROSO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RODENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
550501 - Metabolism- Tracer Techniques