Surfactant release as an early measure of radiation pneumonitis

Journal Article · Tue Nov 01 00:00:00 EST 1983 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(83)90420-0· OSTI ID:5300465

Rubin, P; Siemann, D W; Shapiro, D L; Finkelstein, J N; Penney, D P

The immediate release of surfactant into lung alveoli following irradiation has been studied as a potential indicator for the later development of radiation pneumonitis. Utilizing single dose radiation exposure to the whole thorax in male LAF/sub 1//J mice, steep dose response curves for lavaged alveolar surfactant were identified at 7 and 28 days after exposure. Seven days after irradiation there was no elevation with doses up to and including 12 Gy; above this dose a detectable increase occurred. At 28 days the surfactant recovered by lavage was elevated compared to the levels seen at day 7 for all doses; doses > 12 Gy produced surfactant values significantly greater than those found in mice treated with 12 Gy or less. The radiation pulmonary lethality dose response curve assessed four months later indicated an LD/sub 50/ value of approx. 13 Gy. The early biochemical effect and the later radiation pneumonitis lethalities therefore closely coincided. The evidence strongly indicates that alveolar surfactant release uncovered hours to days after radiation exposure may be an early biochemical marker that predicts for subsequent pneumonitis radiation injury.

• Research Organization: Univ. of Rochester Cancer Center, NY
• OSTI ID: 5300465
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 9:11
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
LUNGS
BIOLOGICAL RADIATION EFFECTS
ULTRASTRUCTURAL CHANGES
PNEUMONITIS
RADIOINDUCTION
SURFACTANTS
BIOCHEMISTRY
CESIUM 137
CHEST
DOSE-RESPONSE RELATIONSHIPS
GAMMA RADIATION
LETHAL RADIATION DOSE
MICE
ALKALI METAL ISOTOPES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
BODY AREAS
CESIUM ISOTOPES
CHEMISTRY
DOSES
ELECTROMAGNETIC RADIATION
IONIZING RADIATIONS
ISOTOPES
LETHAL DOSES
MAMMALS
MORPHOLOGICAL CHANGES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RESPIRATORY SYSTEM
RODENTS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560152* - Radiation Effects on Animals- Animals
550200 - Biochemistry