Induction of lipid peroxidation by hexachlorocyclohexane, dieldrin, TCDD, carbon tetrachloride, and hexachlorobenzene in rats
Hexachlorobenzene (HCB), 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), hexachlorocyclohexane (HCCH) and dieldrin are all halogenated lipophilic environmental contaminants. A common biologic property of these compounds is their ability to induce hepatic microsomal drug metabolizing enzymes. Furthermore, exposure of laboratory animals to these xenobiotics elicits a number of similar effects including porphyria, hypothyroidism, a wasting syndrome and lethality. Perturbation of membrane lipids and lipid peroxidation may be responsible for at least part of the toxic effects of HCCH. TCDD has been shown to induce lipid peroxidation in hepatic and extrahepatic tissues. Based on the similar toxic manifestations of HCB, HCCH, TCDD and dieldrin, the authors have examined the effects of these xenobiotics on hepatic lipid peroxidation following an acutely toxic dose. Lipid peroxidation was assessed by determining the content of thiobarbituric acid reactive substance (TBARS) in the liver, employing malondialdehyde as the standard. Animals were also treated with carbon tetrachloride, a well know inducer of lipid peroxidation, as a positive control. Furthermore, the ability of these xenobiotics to inhibit selenium dependent glutathione peroxidase (GSHPX) activity was determined.
- Research Organization:
- Univ. of Nebraska Medical Center, Omaha
- OSTI ID:
- 5295810
- Journal Information:
- Bull. Environ. Contam. Toxicol.; (United States), Vol. 40:2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
LIPIDS
OXIDATION
ORGANIC CHLORINE COMPOUNDS
BIOLOGICAL EFFECTS
ORAL ADMINISTRATION
PEROXIDASES
ENZYME ACTIVITY
BENZENE
CARBON TETRACHLORIDE
CHLORINATED AROMATIC HYDROCARBONS
CYCLOHEXANE
DIELDRIN
DIOXIN
ENZYME INDUCTION
GLUTATHIONE
LIVER
MICROSOMES
RATS
SELENIUM COMPOUNDS
XENOBIOTICS
ALKANES
ANIMALS
AROMATICS
BODY
CELL CONSTITUENTS
CHEMICAL REACTIONS
CHLORINATED ALIPHATIC HYDROCARBONS
CYCLOALKANES
DIGESTIVE SYSTEM
DRUGS
ENZYMES
GENE REGULATION
GLANDS
HALOGENATED ALIPHATIC HYDROCARBONS
HALOGENATED AROMATIC HYDROCARBONS
HETEROCYCLIC COMPOUNDS
HYDROCARBONS
INSECTICIDES
MAMMALS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANOIDS
ORGANS
OXIDOREDUCTASES
PEPTIDES
PESTICIDES
POLYPEPTIDES
PROTEINS
RADIOPROTECTIVE SUBSTANCES
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology