16,16-dimethyl prostaglandin E/sub 2/ induces radioprotection in Murine intestinal and hematopoietic stem cells
Exogenous prostaglandins (PGs) have been shown to protect gastrointestinal mucosa, liver, and pancreas from several injurious agents, including the PG inhibitor, indomethacin. Previous studies from this laboratory showed exogenous administration of 16,16-dimethyl (dm) PGE/sub 2/ also protected mouse intestinal stem cells from radiation injury. The present study extended that observation and demonstrated that PGs given to B6D2F1 mice 1 hr before irradiation increased the shoulder of the intestinal clonogenic cell survival curve. PGs increased the LD50/6 from 16.3 + 0.41 in controls to 20.25 + 0.55 Gy. The 16,16-dm PGE/sub 2/ increased the hematopoietic CFU-S survival in a qualitatively similar way. A large number of human tumors secrete a variety of PGs. Our results suggest that those tumors may be, in part, protected from radiation injury.
- Research Organization:
- Rush Univ., Chicago, IL
- DOE Contract Number:
- AC03-76SF00098
- OSTI ID:
- 5265084
- Journal Information:
- Radiat. Res.; (United States), Vol. 103:2
- Country of Publication:
- United States
- Language:
- English
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MICE
LETHAL RADIATION DOSE
PROSTAGLANDINS
RADIOSENSITIVITY EFFECTS
STEM CELLS
BIOLOGICAL RADIATION EFFECTS
BONE MARROW
COBALT 60
COLONY FORMATION
GAMMA RADIATION
INTESTINES
RADIOPROTECTIVE SUBSTANCES
SURVIVAL CURVES
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
COBALT ISOTOPES
DIGESTIVE SYSTEM
DOSES
DRUGS
ELECTROMAGNETIC RADIATION
GASTROINTESTINAL TRACT
HEMATOPOIETIC SYSTEM
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LETHAL DOSES
MAMMALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-ODD NUCLEI
ORGANS
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RODENTS
SOMATIC CELLS
TISSUES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560152* - Radiation Effects on Animals- Animals