Influence of copper status on antioxidant defense and lipid peroxidation following chronic ethanol feeding in the rat

Conference · Mon Mar 11 00:00:00 EST 1991 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:5264967

Greco, D J; Zidenberg-Cherr, S; Han, B; Rosenbaum, J; Keen, C L ^[1]

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1. Univ. of California, Davis (United States)

The effects of chronic ethanol (Et) consumption on liver antioxidant defense and lipid peroxidation were assessed in Cu sufficient (+Cu) and deficient ({minus}Cu) rats fed liquid diets with Et or dextrose (C) at 36% of kcals for 2 mo. Rats in the Et groups consumed less calories than those in the non-Et groups, thus a restricted intake group (RI) was included to account for any effects due to caloric restriction. Et feeding resulted in lower Cu and Zn and higher Mn concentrations in +Cu and {minus}Cu rats relative to C rats. Both Cu intake and Et resulted in lower CuZn superoxide dismutase (CuSOD) and glutathione peroxidase activities relative to C rats. CuZnSOD and GPx activities were lowest in {minus}CuEt rats; values were 50% of C values. In contrast, Et feeding resulted in higher MnSOD activity in +Cu and {minus}Cu rats. Despite a limited antioxidant defense system in the {minus}Cu rats, Et had no effect on mitochondrial lipid peroxidation as assessed by thiobarbituric acid reacting substances (TBARS). In contrast, microsomal TBRS production was lower in the Et fed groups; the lowest values occurring in the {minus}CuEt rats. These results suggest that in the Cu deficient animal, despite reductions in some components of the antioxidant defense system, compensatory mechanisms can arise which result in a reduction in peroxidation targets and/or an increase in alternate free radical quenching factors.

• OSTI ID: 5264967
• Report Number(s): CONF-9104107-; CODEN: FAJOE
• Journal Information: FASEB Journal (Federation of American Societies for Experimental Biology); (United States), Vol. 5:4; Conference: 75. annual meeting of the Federation of American Societies for Experimental Biology (FASEB), Atlanta, GA (United States), 21-25 Apr 1991; ISSN 0892-6638
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
COPPER
BIOLOGICAL EFFECTS
ETHANOL
LIPIDS
METABOLISM
CHRONIC EXPOSURE
ENZYME ACTIVITY
GLUTATHIONE
LIVER
MICROSOMES
MITOCHONDRIA
NUTRITIONAL DEFICIENCY
PEROXIDASES
RATS
SUPEROXIDE DISMUTASE
ALCOHOLS
ANIMALS
BODY
CELL CONSTITUENTS
DIGESTIVE SYSTEM
DRUGS
ELEMENTS
ENZYMES
GLANDS
HYDROXY COMPOUNDS
MAMMALS
METALS
ORGANIC COMPOUNDS
ORGANS
OXIDOREDUCTASES
PEPTIDES
POLYPEPTIDES
PROTEINS
RADIOPROTECTIVE SUBSTANCES
RIBOSOMES
RODENTS
TRANSITION ELEMENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology