Antireceptor antiserum causes specific inhibition of reactivity to rat histocompatibility antigens

Journal Article · Fri Jan 11 00:00:00 EDT 1974 · Science; (United States)

DOI:https://doi.org/10.1126/science.183.4120.94· OSTI ID:5237454

McKearn, T J

The antigen receptor of lymphocytes destined to form antibody appears to have the characteristics of the immunoglobulin produced. Antibody directed against the combining region of this immunoglobulin should interact with the combining region of the cell receptor for the antigen. Purified Lewis rat alloantibody prepared against Brown Norway (BN) rat histocompatibility antigens was used to immunize L x BN F/sub 1/ hybrids. The resultant antiserum has antireceptor activity because (i) it yields precipitin lines in gel diffusion when reacted against the immunizing alloantibody; (ii) it inhibits the hemagglutinin antibody response of Lewis rats to BN histocompatibility antigens; and (iii) it inhibits the local graft-versus-host response of Lewis lymphoid cells against BN antigens. This suggests that antireceptor antibody may inhibit cell-mediated responses as well as antibody responses to histocompatibility antigens and may play a role in the regulation of immune responses to such antigens.

• Research Organization: Univ. of Chicago
• OSTI ID: 5237454
• Journal Information: Science; (United States), Vol. 183
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ANTIBODIES
COMPLEMENT
FIBROSARCOMAS
ANTIGEN-ANTIBODY REACTIONS
LYMPHOCYTES
GRAFT-HOST REACTION
RATS
IMMUNITY
ANTIBODY FORMATION
BLOOD PLASMA
IMMUNOGLOBULINS
IMMUNOLOGY
PATHOLOGICAL CHANGES
TISSUE CULTURES
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DISEASES
GLOBULINS
LEUKOCYTES
MAMMALS
NEOPLASMS
ORGANIC COMPOUNDS
PROTEINS
RODENTS
SARCOMAS
SOMATIC CELLS
VERTEBRATES
550900* - Pathology
550200 - Biochemistry