Phase I-II study of concurrent irradiation and multi-drug chemotherapy in advanced carcinoma of the breast: a pilot study by the Southeastern Cancer Study Group
A pilot study was begun by SECSG in October, 1976 for the treatment of patients with advanced inoperable carcinoma of the breast (stage T3-T4, N2-N3) without distant metastasis. Two courses of chemotherapy (5-FU, cytoxan, Adriamycin) are given on days 1 and 28, and after two weeks rest the radiation therapy begins. During the radiation therapy the Adriamycin is discontinued and the 5-FU and cytoxan are given at 60% of the initial dose. Two weeks after the completion of the radiotherapy, the three drugs are reinstated at the initial dose. Cycles are repeated every 28 days for a total of eight after radiotherapy (total one year therapy). The total maximum dose of Adriamycin allowable is 450 mm/m/sup 2/. Radiation therapy in doses of 6500 rad TD to the primary tumor, 6000 rad to the palpable lymph nodes and 4500 rad to electively treated lymph node bearing areas is administered using 4 MeV photons and for the internal mammary nodes 13 MeV electrons. The daily tumor dose is 180 rad, five weekly fractions. A total of 14 patients were entered to the study, five with a diagnosis of inflammatory carcinoma of the breast, five patients with advanced inoperable ductal carcinoma and four with isolated recurrences in the chest wall following a modified radical mastectomy. The primary tumor showed partial regression (50 to 75%) in 65% of the patients following the completion of the radiotherapy. Of the ten patients treated for primary carcinoma of the breast, five are alive without evidence of tumor; only two patients have developed chest wall recurrence, one of them in the posterior chest wall, behind the radiation portals.
- Research Organization:
- Washington Univ. School of Medicine, St. Louis, MO
- OSTI ID:
- 5236627
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 5:8; Conference: Conference on combined modalities: chemotherapy/radiotherapy. Part 1, Hilton Head Island, SC, USA, 15 Nov 1978
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
DOXORUBICIN
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ENDOXAN
FLUOROURACILS
LYMPH NODES
BIOLOGICAL RADIATION EFFECTS
MAMMARY GLANDS
PATIENTS
CARCINOMAS
DOSES
FRACTIONATED IRRADIATION
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AZINES
BIOLOGICAL EFFECTS
BODY
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GLANDS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IRRADIATION
LYMPHATIC SYSTEM
NEOPLASMS
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ORGANIC FLUORINE COMPOUNDS
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ORGANIC NITROGEN COMPOUNDS
ORGANS
PYRIMIDINES
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