Assessment of the (/sup 18/F) fluorodeoxyglucose kinetic model in calculations of myocardial glucose metabolism during ischemia. [Rabbits]

Journal Article · Tue Nov 01 00:00:00 EST 1983 · J. Nucl. Med.; (United States)

OSTI ID:5234361

Marshall, R C; Huang, S C; Nash, W W; Phelps, M E

The lumped constant - a term in the operational equation of the Sokoloff tracer kinetic model for deoxyglucose that accounts for the difference in transport and phosphorylation between glucose and its analog, deoxyglucose - could potentially vary from normal to ischemic conditions in the heart. To test the stability of the lumped constant during ischemia, the authors evaluated the ratio of the extraction fraction for (F-18)-fluorodeoxyglucose (FDG) to that for glucose(a measure of the lumped constant if there is no significant dephosphorylation of FDG-6-PO/sub 4/) and the rate constant for dephosphorylation of FDG-6-/sub 4/(k/sub 4/) in the isolated, arterially perfused interventricular septum of the rabbit during moderate and severe demand-induced and reduced-flow ischemias. The lumped constant and k/sub 4/* in each of the four ischemic experimental conditions were found not to be significantly different from the value obtained from the nonischemic controls.

• Research Organization: Univ. of California, Los Angeles
• OSTI ID: 5234361
• Journal Information: J. Nucl. Med.; (United States), Vol. 24:11
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
FLUORINE 18
METABOLISM
HEXOSES
MYOCARDIUM
RADIONUCLIDE KINETICS
BIOLOGICAL MODELS
COMPARTMENTS
GLUCOSE
ISCHEMIA
RABBITS
ALDEHYDES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARBOHYDRATES
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
DISEASES
FLUORINE ISOTOPES
HEART
HOURS LIVING RADIOISOTOPES
ISOTOPES
LIGHT NUCLEI
MAMMALS
MONOSACCHARIDES
MUSCLES
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
SACCHARIDES
VASCULAR DISEASES
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
550501 - Metabolism- Tracer Techniques