Effects of age and sex on copper absorption, turnover, and status
- Dept. of Agriculture, Grand Forks, ND (United States)
Healthy, free-living men and women aged 20 to 59 years were studied to determine the effects of age and sex on Cu absorption, biological half-life (BH) and status. Additional women who were taking oral contraceptives (OCH) or estrogens were compared to women the same ages who did not take hormones. After an overnight fast, subjects provided a blood sample and ate breakfast labeled with 2.5 {mu}Ci Cu-67. Total Cu-67 ingested was determined after the meal by counting subjects in a whole-body gamma counter. Whole body retention of Cu-67 was monitored by 10 additional counts during the next 21 days. Cu absorption (%A) was calculated by extrapolation of the linear portion of a semi-log plot of % retention vs time. BH was {minus}1n2/slope. %A was significantly greater in women than men aged 20-50, but was not affected by age. BH was not significantly affected by either age or sex. Plasma Cu, enzymatic ceruloplasmin (Cp), and RID Cp were significantly higher in women than men, but SOD and in vitro Cu-67 uptake by RBCs did not differ. None of the biochemical indices were significantly affected by age, except RID Cp, which increased with age. Plasma Cu, enzymatic Cp, and SOD activity were higher in women aged 20-39 taking OCH than in those not taking OCH, but %A and BH did not differ between the groups. Trends in women 50-59 taking estrogen or not were similar to findings for women with/without OCH. These data suggest that dietary Cu requirements may differ between men and women.
- OSTI ID:
- 5214244
- Report Number(s):
- CONF-9104107-; CODEN: FAJOE
- Journal Information:
- FASEB Journal (Federation of American Societies for Experimental Biology); (United States), Vol. 5:5; Conference: 75. annual meeting of the Federation of American Societies for Experimental Biology (FASEB), Atlanta, GA (United States), 21-25 Apr 1991; ISSN 0892-6638
- Country of Publication:
- United States
- Language:
- English
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COPPER
METABOLISM
AGE DEPENDENCE
BIOLOGICAL HALF-LIFE
CERULOPLASMIN
COPPER 67
ERYTHROCYTES
INTESTINAL ABSORPTION
RETENTION
SEX DEPENDENCE
SUPEROXIDE DISMUTASE
TRACER TECHNIQUES
ABSORPTION
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
COMPLEXES
COPPER COMPLEXES
COPPER ISOTOPES
DAYS LIVING RADIOISOTOPES
ELEMENTS
ENZYMES
GLOBULINS
GLOBULINS-ALPHA
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
MATERIALS
METALLOPROTEINS
METALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
OXIDOREDUCTASES
PROTEINS
RADIOISOTOPES
TRANSITION ELEMENT COMPLEXES
TRANSITION ELEMENTS
UPTAKE
560300* - Chemicals Metabolism & Toxicology