Distinct development patterns of c-mos protooncogene expression in female and male mouse germ cells

Journal Article · Sat Aug 01 00:00:00 EDT 1987 · Proc. Natl. Acad. Sci. U.S.A.; (United States)

DOI:https://doi.org/10.1073/pnas.84.15.5301· OSTI ID:5208258

Mutter, G L; Wolgemuth, D J

The protooncogene c-mos is expressed in murine reproductive tissues, producing transcripts of 1.7 and 1.4 kilobases in testis and ovary, respectively. In situ hybridization analysis of c-mos expression in histological sections of mouse ovaries revealed that oocytes are the predominant if not exclusive source of c-mos transcripts. /sup 35/S- or /sup 32/P-labelled RNA probes were transcribed. c-mos transcripts accumulate in growing oocytes, increasing 40- to 90-fold during oocyte and follicular development. c-mos transcripts were also detected in male germ cells and are most abundant after the cells have entered the haploid stage of spermatogenesis. This developmentally regulated pattern of c-mos expression in oocytes and spermatogenic cells suggest that the c-mos gene product may have a function in normal germ-cell differentiation or early embryogenesis.

• Research Organization: Columbia Univ. College of Physicians and Surgeons, New York, NY (USA)
• OSTI ID: 5208258
• Journal Information: Proc. Natl. Acad. Sci. U.S.A.; (United States), Vol. 84:15
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
MESSENGER-RNA
AUTORADIOGRAPHY
HYBRIDIZATION
ONCOGENES
GENE REGULATION
GERM CELLS
LIVER
MICE
OVARIES
PHOSPHORUS 32
SULFUR 35
TESTES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
EVEN-ODD NUCLEI
FEMALE GENITALS
GENES
GLANDS
GONADS
ISOTOPES
LIGHT NUCLEI
MALE GENITALS
MAMMALS
NUCLEI
NUCLEIC ACIDS
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
PHOSPHORUS ISOTOPES
RADIOISOTOPES
RNA
RODENTS
SULFUR ISOTOPES
VERTEBRATES
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550201 - Biochemistry- Tracer Techniques