Comparative metabolism and fate of fenvalerate in Japanese quail (Coturnix coturnix japonica) and rats (Rattus norwegicus)
The distribution, elimination and metabolism of fenvalerate, ..cap alpha..-cyano-3-phenoxy-benzyl-2-(4-chlorophenyl) isovalerate, was studied in Japanese quail. Adult birds were administered 100 mg/kg chlorophenyl labeled (/sup 14/C)-fenvalerate and the excreta collection at designated time intervals. At the termination of the study, 72 hours post-dosing, tissues were removed for residue analysis. It was found that 90% of the administered dose was eliminated in the excreta within the first 24 hours. Chloroform extracts of the excreta samples were subjected to thin layer chromatography (TLC) and radioautography. Radioassay following combustion analysis of tissues showed the presence of extremely low residue levels in brain, heart, lung, kidney and liver. Fat and skin appear to accumulate residues but still the levels were very low. Time-course studies of fenvalerate reveal that the radiocarbon peaks at 3 hours (9 ..mu..g/g) in the liver and gradually declines while in the blood it peaks within 2 hours and falls quickly to an equilibrium value of 1.5 ..mu..g/ml blood. The rapid excretion, lesser absorption and faster metabolism of fenvalerate probably explain the lower toxicity of this pesticide to birds compared to rats.
- Research Organization:
- Maryland Univ., College Park (USA)
- OSTI ID:
- 5179385
- Resource Relation:
- Other Information: Thesis (Ph. D.)
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
INSECTICIDES
CHEMICAL COMPOSITION
METABOLISM
ADIPOSE TISSUE
AUTORADIOGRAPHY
BIRDS
BLOOD
BRAIN
CARBON 14 COMPOUNDS
COMPARATIVE EVALUATIONS
EXCRETION
HEART
ISOVALERIC ACID
KIDNEYS
LIVER
LUNGS
RATS
SKIN
TISSUE DISTRIBUTION
TRACER TECHNIQUES
ANIMAL TISSUES
ANIMALS
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM
CLEARANCE
CONNECTIVE TISSUE
DIGESTIVE SYSTEM
DISTRIBUTION
GLANDS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MATERIALS
MONOCARBOXYLIC ACIDS
NERVOUS SYSTEM
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PESTICIDES
RESPIRATORY SYSTEM
RODENTS
TISSUES
VERTEBRATES
550501* - Metabolism- Tracer Techniques