Influence of cadmium on the intestinal uptake and absorption of calcium in the rat
- Comparative Animal Research Lab., Oak Ridge, TN
To determine the effects of cadmium on the intestinal absorption of calcium, everted gut sacs from rats orally dosed with 0, 0.05, 0.5 or 5.0 mg Cd daily for 3 weeks were placed in media containing 4 x 10/sup -5/ M Ca. Tissue content of calcium after 1 hour incubation was approximately 1.5 times greater for the 5-mg Cd dose. Serosal fluid content of calcium was decreased by the 0.5- and 5-mg Cd/day doses. In other experiments, gut sacs were incubated in bathing media containing 4 x 10/sup -5/ Ca and Cd in concentrations of 10/sup -4/ to 10/sup -2/ M. Tissue and serosal fluid uptake of calcium decreased as Cd concentration increased. To determine the effects of cadmium on the accumulation of calcium against a concentration gradient, equimolar concentrations of Cd were placed in the mucosal and serosal fluids. Cadmium was added to the mucosal fluid. The accumulation of calcium was abolished by 1.5 x 10/sup -4/ M Cd while at 10/sup -6/ M Cd the accumulation was decreased to one-third the control value. The results indicate that acute or chronic exposure of the intestine to cadmium decreases the intestinal absorption of calcium.
- DOE Contract Number:
- DE-AC05-760R00242
- OSTI ID:
- 5172050
- Journal Information:
- J. Nutr.; (United States), Vol. 111:4
- Country of Publication:
- United States
- Language:
- English
Similar Records
Development of in vitro calcium (Ca) transport in the spontaneously hypertensive (SH) and wistar Kyoto (WK) rat
Does glucose enhance intestinal calcium absorption by a cellular pathway
Related Subjects
CADMIUM
BIOLOGICAL EFFECTS
CALCIUM 45
BIOLOGICAL ACCUMULATION
INTESTINAL ABSORPTION
RATS
ABSORPTION
ALKALINE EARTH ISOTOPES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CALCIUM ISOTOPES
DAYS LIVING RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
ISOTOPES
MAMMALS
METALS
NUCLEI
RADIOISOTOPES
RODENTS
UPTAKE
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)