Closing capacity in awake and anesthetized-paralyzed man. [/sup 133/Xe]

Journal Article · Wed Feb 01 00:00:00 EST 1978 · J. Appl. Physiol.; (United States)

OSTI ID:5151067

Juno, J; Marsh, H M; Knopp, T J; Rehder, K

Functional residual capacity (FRC), closing capacity (CC), and (FRC--CC) were determined in 61 supine patients using the /sup 133/Xe bolus test. In 28 of the 61 patients measurements were made both while the patients were awake and during anesthesia-paralysis. both FRC and CC decreased significantly after induction of anesthesia-paralysis. The magnitude of the reduction in CC, but not of FRC, was dependent on the relationship between FRC and CC in the awake state. Patients whose FRC was larger than their CC while awake (group I) showed less decrease in CC than FRC, i.e., (FRC--CC) decreased. By contrast, those patients whose CC was larger than their FRC while awake (group II) showed a greater decrease in CC than in FRC, i.e., (FRC--CC) became less negative. The reduction in CC after induction of anesthesia-paralysis may result from an increased elastic recoil of the lung. The larger reduction in CC in group II patients may have been due to a larger increase in elastic recoil, possibly due to the development of atelactasis.

• Research Organization: Mayo Clinic and Mayo Foundation, Rochester, MN
• OSTI ID: 5151067
• Journal Information: J. Appl. Physiol.; (United States), Vol. 44:2
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANESTHESIA
BIOLOGICAL EFFECTS
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DYNAMIC FUNCTION STUDIES
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NUCLEI
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RADIOISOTOPES
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