Regulation of pulpal blood flow
The regulation of blood flow of the dental pulp was investigated in dogs and rats anesthetized with sodium pentobarbital. Pulpal blood flow was altered by variations of local and systemic hemodynamics. Macrocirculatory blood flow (ml/min/100 g) in the dental pulp was measured with both the /sup 133/Xe washout and the 15-microns radioisotope-labeled microsphere injection methods on the canine teeth of dogs, to provide a comparison of the two methods in the same tooth. Microcirculatory studies were conducted in the rat incisor tooth with microscopic determination of the vascular pattern, RBC velocity, and intravascular volumetric flow distribution. Pulpal resistance vessels have alpha- and beta-adrenergic receptors. Activation of alpha-receptors by intra-arterial injection of norepinephrine (NE) caused both a reduction in macrocirculatory Qp in dogs and decreases in arteriolar and venular diameters and intravascular volumetric flow (Qi) in rats. These responses were blocked by the alpha-antagonist PBZ. Activation of beta-receptors by intra-arterial injection of isoproterenal (ISO) caused a paradoxical reduction of Qp in dogs. In rats, ISO caused a transient increase in arteriolar Qi followed by a flow reduction; arteriolar dilation was accompanied by venular constriction. These macrocirculatory and microcirculatory responses to ISO were blocked by the alpha-antagonist propranolol.
- Research Organization:
- Columbia Univ., New York, NY
- OSTI ID:
- 5125377
- Journal Information:
- J. Dent. Res.; (United States), Journal Name: J. Dent. Res.; (United States)
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BONE TISSUES
BLOOD FLOW
XENON 133
TRACER TECHNIQUES
BLOOD PRESSURE
DOGS
HEMORRHAGE
MICROSPHERES
RATS
RECEPTORS
SYMPATHOMIMETICS
TEETH
VELOCITY
ANIMAL TISSUES
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CONNECTIVE TISSUE
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DRUGS
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
NUCLEI
ORAL CAVITY
PATHOLOGICAL CHANGES
RADIOISOTOPES
RODENTS
SYMPTOMS
TISSUES
VERTEBRATES
XENON ISOTOPES
551001* - Physiological Systems- Tracer Techniques