Potentiation of the expression of nitrogen dioxide-induced lung injury by postexposure exercise
- Los Alamos National Laboratory, NM (USA)
Groups of Fischer-344 rats were exposed to 100 ppm NO{sub 2} for 15 min, exercised at times ranging from 30 min to 24 hr thereafter, and sacrificed during a 24-hr postexposure period. Other exposed rats were exercised 30 min to 24 hr thereafter and sacrificed for lung studies 30 min following the postexposure exercise (E) runs. Still other exposed animals were exercised immediately and at 8 to 24 hr postexposure and sacrificed 30 min after the last E run. NO{sub 2}-exposed but rested rats, and sham-air-exposed and rested or exercised rates served as controls. E immediately or at 8 hr post-NO{sub 2} exposure caused marked increases in lung wet weight (LWW) and right cranial lobe dry weights (RCLDW) and more pronounced histopathologic disturbances beyond those following NO{sub 2} exposure and rest only. Potentiation of injury was not observed in rats exercised 24 hr after exposure. The pattern of subsidence of the LWW and RCLDW increases after immediate or 8 hr E differed with the increases in the former being more persistent. Two E bouts (30 min and 8 hr postexposure) caused lung changes consistent with an additive effect. E performed immediately after NO{sub 2} exposure extended the window of susceptibility to E beyond 24 hr.
- OSTI ID:
- 5098645
- Journal Information:
- Environmental Research; (USA), Vol. 48:1; ISSN 0013-9351
- Country of Publication:
- United States
- Language:
- English
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EXERCISE
BIOLOGICAL EFFECTS
LUNGS
INJURIES
NITROGEN DIOXIDE
TOXICITY
RATS
ANIMALS
BODY
CHALCOGENIDES
MAMMALS
NITROGEN COMPOUNDS
NITROGEN OXIDES
ORGANS
OXIDES
OXYGEN COMPOUNDS
RESPIRATORY SYSTEM
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology