X-ray sensitivity of human tumor cells in vitro

Journal Article · Tue Apr 01 00:00:00 EST 1980 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(80)90057-7· OSTI ID:5061884

Weichselbaum, R R ^[1]; Nove, J; Little, J B

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1. Harvard Medical School, Boston, MA

Clonally-derived cells from ten human malignant tumors considered radiocurable (breast, neuroblastoma, medulloblastoma) or non-radiocurable (osteosarcoma, hypernephroma, glioblastoma, melanoma) were studied in cell culture and their in vitro x-ray survival curve parameters determined (anti n, D/sub 0/). There were no significant differences among the tumor cell lines suggesting that survival parameters in vitro do not explain differences in clinical radiocurability. Preliminary investigation with density inhibited human tumor cells indicate that such an approach may yield information regarding inherent cellular differences in radiocurability.

• OSTI ID: 5061884
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 6:4
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CLONE CELLS
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BIOLOGICAL RADIATION EFFECTS
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