Delayed radiation injury of gut-exposed and gut-shielded mice. II. The decrement in life span
Two mouse strains (RF/J and C57B1/6J) were exposed to x-ray doses totaling 400, 800, and 1200 rad. Total doses were given in 200-rad fractions at 7-day intervals to the whole body, gut only, or bone tissue with the gut shielded. Animals were anesthetized during exposure. Two control groups were used. A sham control group was anesthetized but not exposed to x rays, and another control group received neither anesthesia nor x-radiation. All mice were retained in a standard laboratory environment for observations on life span and histopathology at death. Life shortening was observed in all irradiated groups of strain RF/J mice and was attributed primarily to an increase in incidence and/or earlier onset of neoplasia. Life shortening was observed in the C57B1/6J whole-body exposed mice, but the effect appeared to be noncarcinogenic. Shielding of the bone or gut tissue proved to have a 100% sparing effect in strain C57 mice and none in strain RF mice. In both mouse strains, the sham control groups (anesthetized but not irradiated) showed approximately 8% life shortening below the non-anesthetized control groups and increased incidences of neoplasia of approximately 40%, suggesting that sodium pentabarbital may be as carcinogenic as x-radiation.
- Research Organization:
- Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
- DOE Contract Number:
- W-7405-ENG-36
- OSTI ID:
- 5038870
- Report Number(s):
- LA-6717-MS(Vol.2); TRN: 78-008689
- Country of Publication:
- United States
- Language:
- English
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MICE
BIOLOGICAL RADIATION EFFECTS
RADIOSENSITIVITY
GENETIC VARIABILITY
BONE TISSUES
DELAYED RADIATION EFFECTS
DOSE RATES
DOSE-RESPONSE RELATIONSHIPS
GASTROINTESTINAL TRACT
LIFE SPAN
PATHOLOGICAL CHANGES
WHOLE-BODY IRRADIATION
X RADIATION
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL VARIABILITY
BODY
CONNECTIVE TISSUE
DIGESTIVE SYSTEM
DISEASES
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
IONIZING RADIATIONS
IRRADIATION
MAMMALS
RADIATION EFFECTS
RADIATIONS
RODENTS
TISSUES
VERTEBRATES
560152* - Radiation Effects on Animals- Animals