Autoantibody to the gastrin receptor in pernicious anemia

Journal Article · Thu Aug 22 00:00:00 EDT 1985 · N.Engl. J. Med.; (United States)

DOI:https://doi.org/10.1056/NEJM198508223130805· OSTI ID:5021832

de Aizpurua, H J; Ungar, B; Toh, B H

The authors examined serum IgG fractions from 20 patients with pernicious anemia and 25 control subjects for their capacity to inhibit binding of (/sup 125/I)15-leu human gastrin-17 to parietal-cell-enriched gastric mucosal cells. IgG fractions from six patients reduced gastrin binding by 45.6 +/- 12.2 per cent, as compared with a reduction of 1.8 +/- 0.7 per cent by fractions from the 25 controls. The fractions from these six patients also reduced gastrin-stimulated (/sup 14/C)aminopyrine uptake by gastric cells (an index of gastric acid secretory activity in vitro) by 50.2 +/- 8.4 per cent (mean +/- S.D.), as compared with 9.2 +/- 4.1 per cent for the controls. IgG fractions from six other patients that did not reduce gastrin binding also inhibited gastrin-stimulated (/sup 14/C)aminopyrine uptake, by 48.1 +/- 9.1 per cent. These reductions in gastrin binding and aminopyrine uptake were abolished by absorption of the IgG fractions with suspensions of viable gastric mucosal cells but not by absorption with liver or kidney cells. The IgG fractions did not inhibit (/sup 3/H)histamine binding or histamine-stimulated (/sup 14/C)aminopyrine uptake. These results suggest that serum IgG from some patients with pernicious anemia contains autoantibodies to the gastrin receptor.

• Research Organization: Monash Univ. Medical School, Victoria, Australia
• OSTI ID: 5021832
• Journal Information: N.Engl. J. Med.; (United States), Vol. 8
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ANTIPYRETICS
UPTAKE
GASTRIN
RECEPTORS
ANEMIAS
BIOCHEMICAL REACTION KINETICS
CARBON 14
HISTAMINE
IMMUNOGLOBULINS
IODINE 125
LABELLED COMPOUNDS
PATIENTS
TRACER TECHNIQUES
TRITIUM
AMINES
AZOLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CARBON ISOTOPES
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DAYS LIVING RADIOISOTOPES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-EVEN NUCLEI
GLOBULINS
HEMIC DISEASES
HETEROCYCLIC COMPOUNDS
HORMONES
HYDROGEN ISOTOPES
IMIDAZOLES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
KINETICS
LIGHT NUCLEI
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PEPTIDE HORMONES
PEPTIDES
POLYPEPTIDES
PROTEINS
RADIOISOTOPES
REACTION KINETICS
SYMPTOMS
YEARS LIVING RADIOISOTOPES
550201* - Biochemistry- Tracer Techniques