/sup 125/I-hippuran absorption from the human renal pelvis
The absorption of /sup 125/I-hippuran from human renal pelvis was studied peroperatively in 18 patients with obstruction at the pelviureteric junction. Three types of experiment were included: absorption during induced diuresis, absorption at a constant intrapelvic pressure of 30 cm. H/sub 2/O, and excretion of the indicator by the contralateral kidney. Total and separate glomerular filtration rate were measured using /sup 51/Cr-EDTA clearance technique and isotope renography. Distal tubular function was evaluated as maximum concentration ability. During induced diuresis the intrapelvic pressure increased to an average maximum value of 31.6 cm. H/sub 2/O. The excretion of isotope from the contralateral kidney varied from one to 44% of the given dose. A significant correlation (r = 0.87) between the maximum intrapelvic pressure obtained and the amount of isotope excreted from the contralateral kidney was demonstrated. At a constant intrapelvic pressure of 30 cm. H/sub 2/O the excretion of isotope from the contralateral kidney varied from two to 26% of the dosage given. The low value probably depended on the impaired function of the obstructed kidney. Our results show the existence of a significant reflux from the renal pelvis of small molecules, which was affected by renal function, intrapelvic pressure and volume.
- Research Organization:
- Sahlgrenska Sjukhuset, Goeteborg, Sweden
- OSTI ID:
- 5020540
- Journal Information:
- J. Urol.; (United States), Vol. 3
- Country of Publication:
- United States
- Language:
- English
Similar Records
A TECHNIC FOR KIDNEY SCANNING
Renographic evaluation of kidney preservation with chlorpromazine. [In vitro and in vivo studies with /sup 125/I-Hippuran in rabbit kidneys]
Related Subjects
HIPPURIC ACID
UPTAKE
IODINE 125
CHROMIUM 51
EDTA
EXCRETION
KIDNEYS
PATIENTS
RENAL CLEARANCE
RENOGRAPHY
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BIOMEDICAL RADIOGRAPHY
BODY
CARBOXYLIC ACIDS
CHELATING AGENTS
CHROMIUM ISOTOPES
CLEARANCE
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
MEDICINE
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
RADIOLOGY
550601* - Medicine- Unsealed Radionuclides in Diagnostics