Scavenger receptor for malondialdehyde-modified high density lipoprotein on rat sinusoidal liver cells
The presence of a membrane-associated receptor which mediates endocytic uptake of malondialydehyde-modified high density lipoprotein (MDA-HDL) on sinusoidal liver cells is reported. Binding of (/sup 125/I)MDA-HDL to the cells was followed by internalization and degradation in lysosomes. The binding and lysomal degradation of (/sup 125/I)MDA-HDL were effectively inhibited by unlabeled MDA-HDL and acetyl-HDL. However, formaldehyde-treated serum albumin or low density lipoprotein modified either by acetylation or malondialdehyde, ligands known to undergo receptor-mediated endocytosis by sinusoidal liver cells, did not affect the binding of (/sup 175/I)MDA-HDL to the cells. These results indicate that a receptor for MDA-HDL is described as a distinct member among the scavenger receptors for chemically modified proteins.
- Research Organization:
- Kumamoto Univ. Medical School, Japan
- OSTI ID:
- 5009170
- Journal Information:
- Biochem. Biophys. Res. Commun.; (United States), Vol. 137:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
LIPOPROTEINS
BIOCHEMICAL REACTION KINETICS
LIVER CELLS
RECEPTORS
ACETYLATION
ALBUMINS
ALDEHYDES
BIODEGRADATION
BLOOD SERUM
CELL MEMBRANES
EXPERIMENTAL DATA
INHIBITION
IODINE 125
LABELLED COMPOUNDS
LIGANDS
LYSOSOMES
MALONIC ACID
RESPONSE MODIFYING FACTORS
TRACER TECHNIQUES
ACYLATION
ANIMAL CELLS
BETA DECAY RADIOISOTOPES
CARBOXYLIC ACIDS
CELL CONSTITUENTS
CHEMICAL REACTIONS
DATA
DAYS LIVING RADIOISOTOPES
DECOMPOSITION
DICARBOXYLIC ACIDS
ELECTRON CAPTURE RADIOISOTOPES
INFORMATION
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
KINETICS
LIPIDS
MEMBRANE PROTEINS
MEMBRANES
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANOIDS
PROTEINS
RADIOISOTOPES
REACTION KINETICS
SOMATIC CELLS
550201* - Biochemistry- Tracer Techniques