SYNTHESIS OF ANTIRADIATION DRUGS. Annual Progress Report, April 1, 1961- March 31, 1962
Forty-eight compounds were synthesized and evaluated as potential antiradiation drugs. These compounds were mainly N-substituted derivatives of 2- aminoethanethiol and were supplied as the hydrochloride salts. The synthetic methods used were: thiolethylation of amines and alkanolamines with ethylene sulfide; amination of epoxides and alpha, omega-alkylene dinalides with 2- (Benzylthio)ethylamine, followed by debenzylation; and alkylation of alkanolamines with benzyl 2-chloroethyl sulfide, followed by debenzylation. A study of the reaction variables in the ethylene sulfide thiolethylation of a simple aliphatic amine (n-hexylamine) was begun. The data indicate that high amine: episulfide molar ratios and long reflux periods favor formation of the monothiolethylated product in good yield. (auth)
- Research Organization:
- Monsanto Research Corp. Boston Labs., Everett, Mass.
- DOE Contract Number:
- DA-49-193-MD-2109
- NSA Number:
- NSA-17-012172
- OSTI ID:
- 4763179
- Report Number(s):
- AD-278124
- Resource Relation:
- Other Information: Orig. Receipt Date: 31-DEC-63
- Country of Publication:
- United States
- Language:
- English
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