RADIOCALCIUM UPTAKE IN THE CALCIFIED TISSUES OF RHESUS MONKEYS AT VARIOUS TIME INTERVALS
Uptake of Ca/sup 45/ in skeletal and dental tissues of adult rhesus monkeys was studied at 5-, 27-, 51-, and 168-hr intervals after intravenous Ca/ sup 45/ administration. In all calcified tissues the uptake was highest in the layer adjacent to its tissue-fluid environment, irrespective of whether this was connective-tissue fluid, serum, or saliva. Decreasing Ca/sup 45/ uptake gradients from the internal dentin and surface enamel toward the dentino-enamel junction and from the subperiosteal and subendosteal layers toward the central layer in both long and flat bones were observed. The uptake in the sutural area of the calvarium was higher than in the adjacent bone. An increasing specific activity ratio from the 5-hr sample to the 168-hr sample was observed in each corresponding layer of the bones and teeth. In contrast to the low specific activity ratios of calcified tissues the specific activity ratios of the soft tissues indicated that their Ca at the time of sacrifice was in complete equilibration with Ca in blood. The highest level of Ca/sup 45/ was excreted in urine during the first day, totaling 12.3%, with a relatively consistent low excretion each day thereafter. A total of 18.1% of injected Ca/sup 45/ was excreted in 168 hr. (TCO)
- Research Organization:
- Harvard, Univ., Boston
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-17-027039
- OSTI ID:
- 4662752
- Journal Information:
- J. Dental Res., Vol. Vol: 42; Other Information: Orig. Receipt Date: 31-DEC-63
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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